INT295285

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)

Anatomy Link Frequency microglia 2 Kcnma1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cva 11 5.00 Inflammation 9 5.00 Action potential 2 5.00 Hippocampus 2 5.00 Migraine 1 5.00 Spinal cord 1 5.00 cytokine 1 5.00 midbrain 1 5.00 Inflammatory response 1 5.00 Neuronal excitability 1 5.00

Disease Link Frequency Relevance Heat Drug Induced Neurotoxicity 5 50.00 Stroke 21 5.00 Cv General 4 Under Development 10 5.00 INFLAMMATION 10 5.00 Apoptosis 6 5.00 Schizophrenia 3 5.00 Injury 3 5.00 Disease 3 5.00 Death 2 5.00 Overdose 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Effects of apamin on microglia are most likely due to SK3 channel block because KCNN2 was nearly undetectable in LPS-activated microglia, and rodent KCNN1 apparently does not form functional channels [44,45].

Positive_regulation (due) of Negative_regulation (block) of channel in microglia

1) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.