INT295336

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.31
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Grb7, Xpo1) RNA binding (Grb7, Xpo1) nucleoplasm (Xpo1)
protein transporter activity (Xpo1) cytosol (Grb7) lipid binding (Grb7)
Grb7 (Rattus norvegicus)
Xpo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 70 93.84 High High
opioid receptor 20 5.00 Very Low Very Low Very Low
Dynorphin 15 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 70 93.84 High High
Pain 10 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Diuresis 5 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRM1 was found in association with Grb7 and HuR, and the association was almost completely abolished upon treatment with the CRM1 inhibitor leptomycin B (LMB; Fig. 3 B), suggesting a specific interaction between CRM1 and HuR–Grb7 (Fig. 3 B).
Grb7 Binding (interaction) of CRM1
1) Confidence 0.09 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.16 Pain Relevance 0.08
Although HuR is known to use three different nuclear export machineries, Grb7 is only associated with CRM1 through interaction with HuR.
Grb7 Binding (interaction) of CRM1
2) Confidence 0.09 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Although HuR is known to use three different nuclear export machineries, Grb7 is only associated with CRM1 through interaction with HuR.
Grb7 Binding (associated) of CRM1
3) Confidence 0.09 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
CRM1 was found in association with Grb7 and HuR, and the association was almost completely abolished upon treatment with the CRM1 inhibitor leptomycin B (LMB; Fig. 3 B), suggesting a specific interaction between CRM1 and HuR–Grb7 (Fig. 3 B).
Grb7 Binding (association) of CRM1
4) Confidence 0.09 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.15 Pain Relevance 0.08
These data suggest that other factors or molecules might be involved in either promoting KOR mRNA–Grb7–HuR interaction with CRM1 or prohibiting the interaction of Grb7 with the two transportin complexes.
Grb7 Spec (might) Binding (interaction) of CRM1
5) Confidence 0.09 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0

General Comments

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