INT295346

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Egf, Grb7) lipid binding (Grb7) cytosol (Grb7)
signal transduction (Grb7) extracellular space (Egf) RNA binding (Grb7)
Anatomy Link Frequency
nucleus 2
Egf (Rattus norvegicus)
Grb7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 28 5.00 Very Low Very Low Very Low
opioid receptor 8 5.00 Very Low Very Low Very Low
Dynorphin 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 28 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Diuresis 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig. 5 A, EGF induced an increase in the phosphorylation of cytoplasmic Grb7, which was blocked by FAK inhibitor PF 573228 (Slack-Davis et al., 2007) and FAK inhibitor 14 (Golubovskaya et al., 2008) as well as by silencing FAK.
EGF Positive_regulation (increase) of Phosphorylation (phosphorylation) of Grb7
1) Confidence 0.42 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Fig. 4 E demonstrated that EGF stimulated tyrosine dephosphorylation of Grb7 in the nucleus and enhanced complex formation of Grb7, HuR, and CRM1.
EGF Positive_regulation (stimulated) of Phosphorylation (dephosphorylation) of Grb7 in nucleus
2) Confidence 0.42 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0

General Comments

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