INT295352

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Egf, Grb7) lipid binding (Grb7) cytosol (Grb7)
signal transduction (Grb7) extracellular space (Egf) RNA binding (Grb7)
Egf (Rattus norvegicus)
Grb7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 14 56.40 Quite High
Dynorphin 3 6.12 Low Low
opioid receptor 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 14 56.40 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
Diuresis 1 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that HuR-specific siRNA reduced Grb7 export (Fig. 2 A) and blocked EGF-stimulated cytoplasmic accumulation of Grb7 (Fig. 2 B), which was rescued by expressing siRNA off-target HuR (see Materials and methods).
EGF-stimulated Positive_regulation (accumulation) of Grb7
1) Confidence 0.42 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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