INT295373

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.38
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Grb7) cytosol (Grb7) signal transduction (Grb7)
RNA binding (Grb7) plasma membrane (Grb7) cytoplasm (Grb7)
Anatomy Link Frequency
P19 3
nucleus 2
neurons 1
Grb7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 56 98.76 Very High Very High Very High
opioid receptor 16 5.00 Very Low Very Low Very Low
Dynorphin 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 56 98.76 Very High Very High Very High
Pain 8 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Diuresis 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Silencing of SHP-2 blocked this complex formation (Fig. 4 E) and nuclear export of Grb7 and KOR mRNA (Fig. 4 F), which could be rescued by expressing siRNA off-target Flag–SHP-2 (see Materials and methods).
Negative_regulation (blocked) of Localization (export) of Grb7
1) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
LMB was used to block Grb7 export to obtain a quantitative measure of phosphorylated Grb7 in nucleus versus cytoplasm.
Negative_regulation (block) of Localization (export) of Grb7 in nucleus
2) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.06 Pain Relevance 0.03
This finding was confirmed by immunohistochemical assays in the DRG neurons and P19 cells treated with LMB, in which there was a reduced cytoplasmic localization of Grb7 (Fig. 3 C).
Negative_regulation (reduced) of Localization (localization) of Grb7 in P19 associated with dorsal root ganglion
3) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.16 Pain Relevance 0.08
This finding was confirmed by immunohistochemical assays in the DRG neurons and P19 cells treated with LMB, in which there was a reduced cytoplasmic localization of Grb7 (Fig. 3 C).
Negative_regulation (reduced) of in neurons Localization (localization) of Grb7 in P19 associated with dorsal root ganglion
4) Confidence 0.14 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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