INT295374

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) cytoskeleton (Ptk2)
nucleus (Ptk2) extracellular matrix organization (Ptk2) microtubule organizing center (Ptk2)
Anatomy Link Frequency
nucleus 1
Ptk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 4 80.20 Quite High
dorsal root ganglion 14 5.00 Very Low Very Low Very Low
Dynorphin 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 64.88 Quite High
Ganglion Cysts 14 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
Diuresis 1 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dual action of epidermal growth factor: extracellular signal-stimulated nuclear–cytoplasmic export and coordinated translation of selected messenger RNA

EGF triggers dephosphorylation of the mRNA-binding protein Grb7 in the nucleus, leading to its export, and it also stimulates FAK, which rephosphorylates Grb7 in the cytoplasm to release its mRNA cargo for translation.


Positive_regulation (stimulates) of FAK in nucleus
1) Confidence 0.34 Published 2010 Journal The Journal of Cell Biology Section Title Doc Link PMC2819679 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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