INT295407

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Egf, Oprk1) signal transduction (Oprk1) extracellular space (Egf)
signal transducer activity (Oprk1)
Egf (Rattus norvegicus)
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 77.36 Quite High
dorsal root ganglion 28 76.40 Quite High
opioid receptor 8 72.76 Quite High
Dynorphin 6 46.80 Quite Low
Disease Link Frequency Relevance Heat
Pain 4 77.36 Quite High
Stress 2 76.60 Quite High
Ganglion Cysts 28 76.40 Quite High
Diuresis 2 75.84 Quite High
Cognitive Disorder 2 61.48 Quite High
Targeted Disruption 2 58.80 Quite High
Death 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF mediates Grb7-dependent activation of KOR levels and KOR mRNA nuclear export
EGF Positive_regulation (mediates) of Localization (export) of KOR
1) Confidence 0.02 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.52 Pain Relevance 0.29
Together, these data suggest that EGF triggers KOR mRNA nuclear export in a Grb7-dependent manner.


EGF Positive_regulation (triggers) of Localization (export) of KOR
2) Confidence 0.02 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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