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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.65
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
RT1-Hb-ps1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 1 98.44 Very High Very High Very High
depression 47 91.88 High High
antidepressant 16 90.44 High High
sSRI 4 85.72 High High
Locus ceruleus 1 51.04 Quite High
Neurotransmitter 1 42.16 Quite Low
monoamine 2 33.68 Quite Low
Serotonin 3 13.04 Low Low
sNRI 4 9.12 Low Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 62 96.80 Very High Very High Very High
Diabetes Mellitus 47 86.60 High High
Death 1 53.16 Quite High
Obesity 12 48.00 Quite Low
Overweight 2 39.92 Quite Low
Weight Gain 1 36.12 Quite Low
Chronic Disease 1 25.00 Low Low
Disorder Of Lipid Metabolism 3 5.00 Very Low Very Low Very Low
Weight Loss 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a study with sertraline, glycosylated hemoglobin (HbA1c) levels were reduced during treatment, but did not differ between the sertraline and placebo groups,15,16 whereas no significant reduction in HbA1c levels was observed in patients treated with fluoxetine or paroxetine, although their depressive symptoms were significantly improved.17 Similarly, although escitalopram resulted in a significant reduction of depression score, there was only a small and nonsignificant reduction in fasting blood glucose (FBG) levels and HbA1c levels.18 It would thus appear that selective serotonin reuptake inhibitors (SSRIs) do not have any major effect on metabolic control, even when they produce a significant effect on depressive symptoms.
Neg (no) Negative_regulation (reduction) of Gene_expression (levels) of HbA1c in blood associated with depression, ssri and fluoxetine
1) Confidence 0.08 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2819761 Disease Relevance 1.65 Pain Relevance 0.70

General Comments

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