INT295428

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.01
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT)
nucleus (KIT) cytoplasm (KIT)
KIT (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 2 75.00 Quite High
imagery 2 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 3 97.12 Very High Very High Very High
Cancer 46 95.32 Very High Very High Very High
Gastrointestinal Stromal Tumor 104 95.04 Very High Very High Very High
Leukemia 2 82.72 Quite High
Disease 62 69.20 Quite High
Recurrence 8 67.56 Quite High
Aggression 1 51.60 Quite High
Metastasis 4 41.52 Quite Low
Malignant Neoplastic Disease 1 36.68 Quite Low
Disease Progression 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Imatinib occupies the ATP-binding pocket of KIT, preventing substrate phosphorylation which in turn inhibits downstream signaling, cellular proliferation and cell survival (Figure 1).
Negative_regulation (preventing) of KIT Binding (binding) of associated with hyperplasia
1) Confidence 0.36 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 1.01 Pain Relevance 0.04

General Comments

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