INT295429

Context Info Confidence 0.42 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.84 Pain Relevance 0.07

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT) nucleus (KIT) cytoplasm (KIT)

KIT (Homo sapiens)

Pain Link Frequency Relevance Heat abdominal pain 1 65.80 imagery 2 5.00 Bioavailability 2 5.00 headache 1 5.00 cva 1 5.00 positron emission tomography 1 5.00

Disease Link Frequency Relevance Heat Gastrointestinal Stromal Tumor 104 98.58 Disease 62 82.60 Disease Progression 12 80.40 Asthenia 1 66.32 Abdominal Pain 1 65.80 Diarrhoea 2 65.16 Toxicity 2 60.56 Hypertension 1 9.04 Syndrome 2 8.48 Fatigue 1 7.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, KIT signaling in primary imatinib-resistant GIST shows no evidence of inhibition to imatinib and is similar to that seen in untreated GIST, indicating that KIT primary resistance is associated with persistent KIT phosphorylation and activation of downstream pathways.37 The molecular mechanisms responsible for primary-imatinib resistance differ from those of secondary resistance.

Positive_regulation (activation) of Phosphorylation (phosphorylation) of KIT associated with gastrointestinal stromal tumor

1) Confidence 0.42 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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