INT295429
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In contrast, KIT signaling in primary imatinib-resistant GIST shows no evidence of inhibition to imatinib and is similar to that seen in untreated GIST, indicating that KIT primary resistance is associated with persistent KIT phosphorylation and activation of downstream pathways.37 The molecular mechanisms responsible for primary-imatinib resistance differ from those of secondary resistance. | |||||||||||||||
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General Comments
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