INT295431

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) small molecule metabolic process (CGA) cell-cell signaling (CGA)
signal transducer activity (FSHR) signal transduction (CGA) extracellular region (CGA)
Anatomy Link Frequency
sperm 1
FSHR (Homo sapiens)
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 11 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 3 5 95.72 Very High Very High Very High
Ovarian Hyperstimulation Syndrome 11 88.44 High High
Polycystic Ovary Syndrome 9 36.28 Quite Low
Anovulation 7 27.08 Quite Low
Reprotox - General 2 8 5.00 Very Low Very Low Very Low
Reprotox - General 1 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Endometriosis (extended) 3 5.00 Very Low Very Low Very Low
Abdominal Pain 2 5.00 Very Low Very Low Very Low
Vomiting 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FSH and LH are gonadotropins and have an important role in the process of spermatogenesis, though the actual mechanism of action is poorly understood.133 LH may stimulate testosterone secretion from the Leydig cells of the testicle, while FSH stimulates Sertoli cells to facilitate germ cell differentiation.134 Follitropin alpha alone or with human chorionic gonadotropin (HCG) had been used to improve sperm parameters in male factor infertility.135 A Cochrane review included RCTs that compared pregnancy rates (spontaneous and after ART) following treatment of couples with idiopathic male factor infertility with urinary or recombinant gonadotropins (compared to placebo or no treatment), showed a significantly higher spontaneous pregnancy rate per couple randomized within three months of completing gonadotropin therapy (OR 4.17, 95% CI 1.30 to 7.09).
FSH Positive_regulation (facilitate) of Follitropin alpha in sperm associated with reprotox - general 3
1) Confidence 0.29 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.27 Pain Relevance 0

General Comments

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