INT295432

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
FSHR (Homo sapiens)
PCOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 11 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 9 100.00 Very High Very High Very High
Anovulation 7 92.68 High High
Hyperandrogenism 1 81.76 Quite High
Empty Sella Syndrome 1 66.60 Quite High
Reprotox - General 2 8 65.56 Quite High
Loss Of Sense Of Smell 1 64.16 Quite High
Reprotox - General 1 6 63.80 Quite High
Syndrome 1 63.32 Quite High
Ovarian Hyperstimulation Syndrome 11 5.00 Very Low Very Low Very Low
Reprotox - General 3 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first baby born after ovulation induction by follitropin in a clomiphene resistant PCOS patient was reported in 1992.122 Randomized trials comparing follitropin alpha to other gonadotropins preparation or other ovulatory medications, in infertile women with WHO type II anovulation, have reported a live birth rate of 17% to 20%.59,123,124 The rate of successful ovulation has been reported to be between 57% and 85%.33,125–127 The pooled ovulation rate per cycle after rFSH in clomiphene citrate resistant PCOS women has been calculated to be 71% in a Cochrane review (Figure 2).128 Recent randomized trials have reported higher ovulation rates from 85% and up to 97% in this group of women.59,103,127 with comparable clinical pregnancy rates per woman ranging from 17% to 20% after one cycle,59,103,126 and a cumulative clinical pregnancy rate per woman of 42%.128 A similar cumulative live birth rate of 43% was reported by a subsequent RCT.129
follitropin Positive_regulation (induction) of PCOS associated with polycystic ovary syndrome and anovulation
1) Confidence 0.06 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 1.24 Pain Relevance 0

General Comments

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