INT295439

Context Info Confidence 0.25 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.46 Pain Relevance 0.17

nucleus (AES)

AES (Homo sapiens) IFNA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Multiple sclerosis 88 85.56 depression 4 31.96 antidepressant 1 27.96 corticosteroid 2 5.00 cINOD 2 5.00 Parenteral administration 2 5.00 Central nervous system 1 5.00 adenocard 1 5.00 Inflammation 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Demyelinating Disease 89 85.56 Necrosis 1 55.36 Disease 9 53.28 Lipodystrophy 1 42.88 Depression 4 31.96 Phobia 4 26.72 Cognitive Disorder 6 12.64 Recurrence 9 5.00 Diabetes Mellitus 3 5.00 Chronic Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

One of the most common AEs associated with IFN beta therapy is flu-like symptoms.16 These symptoms tend to appear early in the treatment course, then diminish in frequency and severity with increased time on treatment.

AEs Binding (associated) of IFN

1) Confidence 0.25 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2819898 Disease Relevance 0.46 Pain Relevance 0.17

General Comments

This test has worked.