INT295465

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 49 95.76 Very High Very High Very High
Inflammatory mediators 4 93.44 High High
Spinal cord 9 79.48 Quite High
intrathecal 13 71.88 Quite High
Inflammation 34 67.68 Quite High
cytokine 27 66.64 Quite High
Spontaneous pain 8 62.80 Quite High
tolerance 6 10.92 Low Low
Pain 14 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Cancer 54 95.96 Very High Very High Very High
INFLAMMATION 42 93.04 High High
Insulin Resistance 20 86.08 High High
Obesity 20 72.76 Quite High
Sepsis 63 68.88 Quite High
Polycystic Ovary Syndrome 7 66.84 Quite High
Pain 26 62.80 Quite High
Apoptosis 3 28.56 Quite Low
Infection 5 12.80 Low Low
Hypersensitivity 17 7.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction in TLR4 expression/activation, observed in our study, is in accordance with a previous study that also observed this effect on TLR4 expression/activation with different statins and cell types [51].
Regulation (effect) of Positive_regulation (activation) of TLR4
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.65 Pain Relevance 0.14
At the protein level, whether in the IBCP group (Fig. 6C, E) or in the WBCP group (Fig. 6D, F), data from several western blot experiments revealed a significant up-regulation of the TLR4 (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing) protein in mismatch siRNA- and vehicle-treated bone cancer pain rats relative to that from normal rats.
Regulation (regulation) of Positive_regulation (up) of TLR4 associated with cancer pain and bone cancer
2) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.63 Pain Relevance 0.61

General Comments

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