INT295466

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.33
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 49 95.76 Very High Very High Very High
Inflammation 47 93.04 High High
cytokine 54 92.00 High High
Spinal cord 9 79.48 Quite High
intrathecal 13 71.88 Quite High
Spontaneous pain 8 62.80 Quite High
Inflammatory response 18 43.12 Quite Low
Inflammatory mediators 2 28.32 Quite Low
Pain 14 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 7 99.96 Very High Very High Very High
Bone Cancer 54 95.96 Very High Very High Very High
Disease 4 93.52 High High
INFLAMMATION 65 93.04 High High
Bacterial Infection 4 76.80 Quite High
Polycystic Ovary Syndrome 7 66.84 Quite High
Pain 26 62.80 Quite High
Adult Respiratory Distress Syndrome 4 58.32 Quite High
Targeted Disruption 6 51.92 Quite High
Lung Injury 26 51.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that high VT MV for 4 h induced up-regulation of TLR4 (and not TLR2) protein levels, a receptor related to LPS signal transduction and the classical NF-?
Positive_regulation (induced) of Regulation (regulation) of TLR4
1) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.32 Pain Relevance 0.13
The main findings of this study were the observations that high VT MV, in the absence of infection, induced up-regulation of TLR4 and down-regulation of IRAK3 and I?
Positive_regulation (induced) of Regulation (regulation) of TLR4 associated with infection
2) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.38 Pain Relevance 0.15
At the protein level, whether in the IBCP group (Fig. 6C, E) or in the WBCP group (Fig. 6D, F), data from several western blot experiments revealed a significant up-regulation of the TLR4 (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing) protein in mismatch siRNA- and vehicle-treated bone cancer pain rats relative to that from normal rats.
Positive_regulation (up) of Regulation (regulation) of TLR4 associated with cancer pain and bone cancer
3) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.63 Pain Relevance 0.61

General Comments

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