INT295467

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.94
Pain Relevance 6.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
spinal 2
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 92 99.96 Very High Very High Very High
Cancer pain 343 99.88 Very High Very High Very High
cytokine 148 99.52 Very High Very High Very High
Eae 74 99.24 Very High Very High Very High
Inflammatory mediators 4 98.52 Very High Very High Very High
glial activation 28 97.44 Very High Very High Very High
intrathecal 103 96.08 Very High Very High Very High
Spinal cord 87 95.92 Very High Very High Very High
Pain 116 93.92 High High
Spontaneous pain 60 91.12 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 202 99.96 Very High Very High Very High
Obesity 60 99.92 Very High Very High Very High
Bone Cancer 378 99.72 Very High Very High Very High
Injury 86 99.24 Very High Very High Very High
Nervous System Injury 27 99.08 Very High Very High Very High
Hypersensitivity 121 98.56 Very High Very High Very High
INFLAMMATION 82 98.12 Very High Very High Very High
Pain 206 93.92 High High
Cancer 128 93.44 High High
Insulin Resistance 20 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Attenuation of TLR4 expression by siRNAs
Negative_regulation (Attenuation) of Gene_expression (expression) of TLR4
1) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.64 Pain Relevance 0.57
In this study, we suppressed TLR4 expression using siRNA in a rat CCI model.
Negative_regulation (suppressed) of Gene_expression (expression) of TLR4 associated with eae
2) Confidence 0.43 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2920570 Disease Relevance 0.65 Pain Relevance 0.69
Decreased expression of TLR4 was coincident with decreased expression of the microglial activation markers CD11b (48% in IBCP group; 39% in WBCP group) and CD14 (43%; 30%)(n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).
Negative_regulation (Decreased) of Gene_expression (expression) of TLR4
3) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.49 Pain Relevance 0.55
Down-regulation of Toll-like receptor 4 gene expression by short interfering RNA attenuates bone cancer pain in a rat model

Background

Negative_regulation (regulation) of Gene_expression (expression) of Toll-like receptor 4 gene associated with cancer pain and bone cancer
4) Confidence 0.43 Published 2010 Journal Mol Pain Section Title Doc Link PMC2819998 Disease Relevance 0.75 Pain Relevance 0.64
TLR4 protein expression was significantly reduced following treatment with TLR4 siRNA compared with mismatched siRNA treatment (Fig. 4A,C).
Negative_regulation (reduced) of Gene_expression (expression) of TLR4
5) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.20 Pain Relevance 0.25
As shown in the present study, the knockdown of TLR4 expression leads to attenuation of behavioral hypersensitivity, decreased glial activation, and decreased expression of proinflammatory cytokines.
Negative_regulation (knockdown) of Gene_expression (expression) of TLR4 associated with hypersensitivity, cytokine and glial activation
6) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.38 Pain Relevance 1.25
The most effective siRNA for knocking down TLR4 expression was siRNA439(n = 4, ANOVA1w, P < 0.001, post hoc Dunnett testing).


Negative_regulation (knocking) of Gene_expression (expression) of TLR4
7) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.22 Pain Relevance 0.28
In a complementary study, TLR4 small interfering RNA(siRNA) was administered intrathecally to bone cancer pain rats to reduce the expression of spinal TLR4.
Negative_regulation (reduce) of Gene_expression (expression) of TLR4 in spinal associated with cancer pain and bone cancer
8) Confidence 0.38 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2819998 Disease Relevance 0.98 Pain Relevance 0.89
The reduction in TLR4 expression/activation, observed in our study, is in accordance with a previous study that also observed this effect on TLR4 expression/activation with different statins and cell types [51].
Negative_regulation (reduction) of Gene_expression (expression) of TLR4
9) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.76 Pain Relevance 0.17
Suppression of TLR4 attenuates neuropathic pain in CCI rats
Negative_regulation (attenuates) of Gene_expression (Suppression) of TLR4 associated with eae and neuropathic pain
10) Confidence 0.37 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2920570 Disease Relevance 1.50 Pain Relevance 1.47
TLR-4 protein expression was reduced (p < 0.05) in the trained group when compared with the control group and increased in the recovered group relative to all other groups.
Negative_regulation (reduced) of Gene_expression (expression) of TLR-4 protein
11) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.36 Pain Relevance 0.08

General Comments

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