INT295469

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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.22
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
neutrophils 2
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 26 100.00 Very High Very High Very High
Cancer pain 98 99.32 Very High Very High Very High
cytokine 44 98.72 Very High Very High Very High
Inflammatory response 20 96.08 Very High Very High Very High
Inflammation 110 92.12 High High
Neuropathic pain 16 90.44 High High
Central nervous system 4 88.16 High High
Pain 30 88.00 High High
Spinal cord 18 84.80 Quite High
IPN 10 73.40 Quite High
Disease Link Frequency Relevance Heat
Bone Cancer 108 99.52 Very High Very High Very High
INFLAMMATION 148 95.72 Very High Very High Very High
Neuropathic Pain 40 90.44 High High
Pain 54 88.00 High High
Polycystic Ovary Syndrome 14 79.44 Quite High
Inflammatory Pain 10 73.40 Quite High
Breast Cancer 4 63.16 Quite High
Cancer 38 58.72 Quite High
Hyperalgesia 8 54.88 Quite High
Metastasis 2 52.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal TLR4 siRNA439 attenuates bone cancer pain in the rat model
Localization (Intrathecal) of TLR4 siRNA439 associated with cancer pain, bone cancer and intrathecal
1) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.23 Pain Relevance 0.29
release via the microglial TLR4 receptor [7-9].
Localization (release) of TLR4
2) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.36 Pain Relevance 1.27
release from macrophages [63] and neutrophils and neutrophil activation through a Toll-like receptor 4-dependent mechanism [64].
Localization (release) of Toll-like receptor 4-dependent in neutrophil
3) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.31 Pain Relevance 0.16
release from macrophages [63] and neutrophils and neutrophil activation through a Toll-like receptor 4-dependent mechanism [64].
Localization (release) of Toll-like receptor 4-dependent in neutrophils
4) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.31 Pain Relevance 0.16

General Comments

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