INT295472

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (TNF) extracellular matrix organization (TNF) DNA binding (IRF6)
cytoplasm (IRF6) cytosol (IRF6) signal transduction (TNF)
Anatomy Link Frequency
adipocytes 2
IRF6 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 34 96.72 Very High Very High Very High
cytokine 19 89.08 High High
Arthritis 106 22.56 Low Low
Etanercept 3 10.40 Low Low
Infliximab 1 9.44 Low Low
Adalimumab 1 8.24 Low Low
dexamethasone 7 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 69 99.60 Very High Very High Very High
INFLAMMATION 37 96.72 Very High Very High Very High
Cancer 12 53.76 Quite High
Necrosis 3 53.28 Quite High
Apoptosis 12 29.20 Quite Low
Rheumatoid Arthritis 103 22.56 Low Low
Insulin Resistance 3 22.24 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Leukemia 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that in cells expressing the 299D-399T TLR4, LPS activated the transcription factor NFB and increased the expression of IL6 and TNF-.
LPS Positive_regulation (increased) of Gene_expression (expression) of TNF
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.11 Pain Relevance 0.10
Signaling pathways involved in LPS induced TNFalpha production in human adipocytes

Background

LPS Positive_regulation (induced) of Gene_expression (production) of TNFalpha in adipocytes associated with obesity
2) Confidence 0.06 Published 2010 Journal J Inflamm (Lond) Section Title Doc Link PMC2819999 Disease Relevance 0.84 Pain Relevance 0.17

General Comments

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