INT295478

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (IRF6, TLR4) cytosol (IRF6) signal transduction (TLR4)
plasma membrane (TLR4) intracellular (TLR4) nucleus (IRF6)
IRF6 (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 54 100.00 Very High Very High Very High
tolerance 7 83.76 Quite High
Inflammation 81 79.00 Quite High
Kinase C inhibitor 1 72.36 Quite High
cytokine 49 53.40 Quite High
Inflammatory marker 1 19.76 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 75 100.00 Very High Very High Very High
Chronic Disease 2 88.12 High High
INFLAMMATION 95 79.00 Quite High
Injury 31 50.00 Quite Low
Acute-phase Reaction 1 30.80 Quite Low
Alzheimer's Dementia 2 24.00 Low Low
Adhesions 7 19.28 Low Low
Cirrhosis 61 5.00 Very Low Very Low Very Low
Fibrosis 24 5.00 Very Low Very Low Very Low
Apoptosis 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, LPS requires one or several partner components to be present in the FBS in order to activate TLR4.
LPS Positive_regulation (requires) of Positive_regulation (activate) of TLR4
1) Confidence 0.20 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.17 Pain Relevance 0.04
In addition, several lipoproteins such as low-density lipoprotein might be shuttle molecules for LPS; thus, it is possible that TLR4 activation in the in vivo models of obesity is stimulated by LPS bound to FFAs.



LPS Positive_regulation (stimulated) of Spec (possible) Positive_regulation (activation) of TLR4 associated with obesity and agonist
2) Confidence 0.06 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.61 Pain Relevance 0.36

General Comments

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