INT295480

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.08
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MAPK14, TNF) nucleoplasm (MAPK14) intracellular (TNF)
extracellular matrix organization (TNF) response to stress (MAPK14) cytoplasm (MAPK14)
Anatomy Link Frequency
adipocytes 2
MAPK14 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 84.88 Quite High
anesthesia 1 42.00 Quite Low
cytokine 2 39.96 Quite Low
Kinase C inhibitor 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 68 99.32 Very High Very High Very High
INFLAMMATION 15 84.88 Quite High
Overweight 1 52.96 Quite High
Diabetes Mellitus 2 46.60 Quite Low
Metabolic Syndrome 2 44.72 Quite Low
Insulin Resistance 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the first part of this study, we identified the TLR4 signalling pathways activated by LPS (NFkappaB and p38 MAP Kinase), which lead to the secretion of TNFalpha by mature human adipocytes.
p38 MAP Kinase Positive_regulation (lead) of Localization (secretion) of TNFalpha in adipocytes associated with obesity
1) Confidence 0.08 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 1.08 Pain Relevance 0.12

General Comments

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