INT295501

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.21
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmgcr) aging (Hmgcr) endoplasmic reticulum (Hmgcr)
embryo development (Hmgcr)
Hmgcr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 1 74.96 Quite High
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 32 93.52 High High
Hyperlipidemia 4 40.40 Quite Low
Body Weight 3 5.00 Very Low Very Low Very Low
Fatty Liver 2 5.00 Very Low Very Low Very Low
Exsanguination 1 5.00 Very Low Very Low Very Low
Alcoholic Fatty Liver 1 5.00 Very Low Very Low Very Low
Cerebrovascular Disease 1 5.00 Very Low Very Low Very Low
Hypertriglyceridemia 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Cardiovascular Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 2 presented that the gene expression of HMG-CoA reductase, the key enzyme of cholesterol synthesis, suppressed significantly in the cholesterol-fed rats as compared with the control rats, which suggested that the hepatic cholesterol biosynthesis was inhibited by the high dietary cholesterol.
Negative_regulation (suppressed) of Gene_expression (expression) of HMG-CoA reductase associated with disorder of lipid metabolism
1) Confidence 0.26 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2820024 Disease Relevance 0.21 Pain Relevance 0.04

General Comments

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