INT295517

Context Info Confidence 0.32 First Reported 2010 Last Reported 2010 Negated 10 Speculated 0 Reported most in Body Documents 2 Total Number 10 Disease Relevance 0.91 Pain Relevance 0.28

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)

Anatomy Link Frequency islets of Langerhans 10 brain 1 skeletal muscle 1 adrenal glands 1 small intestine 1 Ghrl (Mus musculus)

Pain Link Frequency Relevance Heat Somatostatin 11 99.84 antagonist 13 98.68 Glutamate 10 97.52 Calcium channel 9 92.28 Neuropeptide 12 70.48 sodium channel 99 43.80 TRP channel 10 19.16 Action potential 49 5.00 Serotonin 36 5.00 Central nervous system 10 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 33 96.52 Salivary Gland Disease 18 81.28 Body Weight 9 49.32 Polycystic Kidney Disease 18 16.16 Aids-related Complex 9 5.00 Dysgeusia 9 5.00 Adhesions 9 5.00 Aging 9 5.00 Decapitation 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ghrelin expression is not limited to the stomach, but is found at many other sites such as the small intestine, brain, pituitary, lung, skeletal muscle, islets of Langerhans, adrenal glands, ovary, and testis [22].

Neg (not) Negative_regulation (limited) of Gene_expression (expression) of Ghrelin in islets of Langerhans

1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0

In addition, this hypothalamic effect of ghrelin is independent of somatostatin, the inhibitor of the GH axis, since it is also found in somatostatin knockout mice.

Neg (independent) Negative_regulation (independent) of Gene_expression (effect) of ghrelin associated with targeted disruption and somatostatin

2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2820089 Disease Relevance 0.18 Pain Relevance 0.28

Ghrelin expression is not limited to the stomach, but is found at many other sites such as the small intestine, brain, pituitary, lung, skeletal muscle, islets of Langerhans, adrenal glands, ovary, and testis [22].

Neg (not) Negative_regulation (limited) of in skeletal muscle Gene_expression (expression) of Ghrelin in islets of Langerhans

3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0

Ghrelin expression is not limited to the stomach, but is found at many other sites such as the small intestine, brain, pituitary, lung, skeletal muscle, islets of Langerhans, adrenal glands, ovary, and testis [22].

Neg (not) Negative_regulation (limited) of in pituitary Gene_expression (expression) of Ghrelin in islets of Langerhans

4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0

Ghrelin expression is not limited to the stomach, but is found at many other sites such as the small intestine, brain, pituitary, lung, skeletal muscle, islets of Langerhans, adrenal glands, ovary, and testis [22].

Neg (not) Negative_regulation (limited) of in ovary Gene_expression (expression) of Ghrelin in islets of Langerhans

5) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0

Ghrelin expression is not limited to the stomach, but is found at many other sites such as the small intestine, brain, pituitary, lung, skeletal muscle, islets of Langerhans, adrenal glands, ovary, and testis [22].

Neg (not) Negative_regulation (limited) of in small intestine Gene_expression (expression) of Ghrelin in islets of Langerhans

6) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0

Ghrelin expression is not limited to the stomach, but is found at many other sites such as the small intestine, brain, pituitary, lung, skeletal muscle, islets of Langerhans, adrenal glands, ovary, and testis [22].

Neg (not) Negative_regulation (limited) of in lung Gene_expression (expression) of Ghrelin in islets of Langerhans

7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0

Ghrelin expression is not limited to the stomach, but is found at many other sites such as the small intestine, brain, pituitary, lung, skeletal muscle, islets of Langerhans, adrenal glands, ovary, and testis [22].

Neg (not) Negative_regulation (limited) of in adrenal glands Gene_expression (expression) of Ghrelin in islets of Langerhans

8) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0

Ghrelin expression is not limited to the stomach, but is found at many other sites such as the small intestine, brain, pituitary, lung, skeletal muscle, islets of Langerhans, adrenal glands, ovary, and testis [22].

Neg (not) Negative_regulation (limited) of in testis Gene_expression (expression) of Ghrelin in islets of Langerhans

9) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0

Ghrelin expression is not limited to the stomach, but is found at many other sites such as the small intestine, brain, pituitary, lung, skeletal muscle, islets of Langerhans, adrenal glands, ovary, and testis [22].

Neg (not) Negative_regulation (limited) of in brain Gene_expression (expression) of Ghrelin in islets of Langerhans

10) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.