INT295519

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.75
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ghsr) plasma membrane (Ghsr) signal transducer activity (Ghsr)
Anatomy Link Frequency
arcuate nucleus 2
nerve 1
Ghsr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 111 100.00 Very High Very High Very High
Dopamine 73 100.00 Very High Very High Very High
Ventral tegmentum 69 98.18 Very High Very High Very High
tolerance 36 78.72 Quite High
Neuropeptide 10 77.32 Quite High
Somatostatin 41 75.32 Quite High
Eae 18 65.36 Quite High
alcohol 7 58.92 Quite High
Opioid 9 46.36 Quite Low
opioid receptor 8 45.84 Quite Low
Disease Link Frequency Relevance Heat
Obesity 99 99.28 Very High Very High Very High
Weight Gain 2 99.00 Very High Very High Very High
Appetite Loss 10 98.28 Very High Very High Very High
Body Weight 21 89.40 High High
Impaired Glucose Tolerance 40 79.36 Quite High
Targeted Disruption 129 62.56 Quite High
Decapitation 3 36.08 Quite Low
Diabetes Mellitus 60 32.96 Quite Low
Disease 12 31.08 Quite Low
Lifespan 2 24.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not known if GHSR also localize to GHRH nerve terminals.
Localization (localize) of GHSR in nerve
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0
In addition, ghrelin and GHSR co-localize in the same taste cells, suggesting that ghrelin works in an autocrine manner in taste cells.
Localization (localize) of GHSR
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2939079 Disease Relevance 0 Pain Relevance 0
The ghrelin receptor (GHSR, growth hormone secretagogue receptor-1) is found in several neuronal subtypes in the arcuate nucleus [8]–[11], where a diffuse pattern of ghrelin-containing terminals has been demonstrated [12].
Localization (secretagogue) of GHSR in arcuate nucleus
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.08
The ghrelin receptor (GHSR, growth hormone secretagogue receptor-1) is found in several neuronal subtypes in the arcuate nucleus [8]–[11], where a diffuse pattern of ghrelin-containing terminals has been demonstrated [12].
Localization (secretagogue) of ghrelin receptor in arcuate nucleus
4) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.08
GHSR1a signals via inositol trisphosphate (IP3) generation and Ca2+ release and has constitutive activity [13, 14].
Localization (release) of GHSR1a
5) Confidence 0.62 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0
Interestingly, these differences are masked in HFD fed mice only in their adult stage; in this situation the deletion of GHSR does not prevent DIO or weight gain after weight loss [34].
Localization (deletion) of GHSR associated with appetite loss, obesity and weight gain
6) Confidence 0.62 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.75 Pain Relevance 0.04
Previously, however, we found that only ‘on-target’ placements (in the VTA and LDTg but not in closely adjacent sites) resulted in significant effects of ghrelin or GHS-R1A antagonists on locomotor stimulation and dopamine release using a larger volume (1 µl) for mice (Jerlhag et al. 2007, 2009).
Localization (release) of GHS-R1A associated with ventral tegmentum, dopamine and antagonist
7) Confidence 0.62 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.48

General Comments

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