INT295526

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.08
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) cytoplasm (Ghrl)
Anatomy Link Frequency
neurons 4
pituitary 2
Ghrl (Mus musculus)
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 18 92.00 High High
Somatostatin 33 90.88 High High
Neuropeptide 9 63.84 Quite High
GABAergic 27 58.56 Quite High
antagonist 39 30.48 Quite Low
Calcium channel 27 24.88 Low Low
TRP channel 3 20.80 Low Low
agonist 24 20.40 Low Low
Action potential 66 9.64 Low Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 84.64 Quite High
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripheral ghrelin or GHS induce rapid c-fos expression in GHRH neurons [16], [17], [58].
ghrelin Positive_regulation (induce) of Gene_expression (expression) of c-fos in neurons
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.09
In addition to its direct effects on the pituitary, ghrelin clearly targets GH release indirectly at the level of the arcuate nucleus since: 1) anatomical disconnections between the hypothalamus and the pituitary gland blunt GH secretion induced by GHS in vivo [13], [14]; 2) the GHSR is expressed in GHRH neurons, which trigger GH release by the pituitary gland [8]–[11]; 3) in vivo GHS treatments enhance GHRH secretion in sheep [1], [15] and induce c-fos expression in GHRH neurons in rodents [16].
ghrelin Positive_regulation (induce) of Gene_expression (expression) of c-fos in pituitary
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.06
NPY neurons are the main ghrelin receptor (GHSR)-expressing cells of the arcuate nucleus [9], [10], and they upregulate c-fos expression in response to ghrelin perfusion [5].
ghrelin Positive_regulation (upregulate) of Gene_expression (expression) of c-fos in neurons
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0.08 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox