INT295528

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ghsr) nucleus (Fos) plasma membrane (Ghsr)
DNA binding (Fos) transcription factor binding (Fos) signal transducer activity (Ghsr)
Anatomy Link Frequency
neurons 2
pituitary 2
Ghsr (Mus musculus)
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 22 90.44 High High
Neuropeptide 6 50.56 Quite High
GABAergic 18 45.92 Quite Low
antagonist 26 30.48 Quite Low
Calcium channel 18 24.44 Low Low
gABA 12 24.32 Low Low
agonist 16 20.40 Low Low
TRP channel 2 20.36 Low Low
Action potential 44 9.20 Low Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 16.96 Low Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripheral ghrelin or GHS induce rapid c-fos expression in GHRH neurons [16], [17], [58].
GHS Positive_regulation (induce) of Gene_expression (expression) of c-fos in neurons
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.09
In addition to its direct effects on the pituitary, ghrelin clearly targets GH release indirectly at the level of the arcuate nucleus since: 1) anatomical disconnections between the hypothalamus and the pituitary gland blunt GH secretion induced by GHS in vivo [13], [14]; 2) the GHSR is expressed in GHRH neurons, which trigger GH release by the pituitary gland [8]–[11]; 3) in vivo GHS treatments enhance GHRH secretion in sheep [1], [15] and induce c-fos expression in GHRH neurons in rodents [16].
GHS Positive_regulation (induce) of Gene_expression (expression) of c-fos in pituitary
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.03

General Comments

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