INT295530

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.21
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl, Ghrh) extracellular region (Ghrl, Ghrh) cytoplasm (Ghrl)
Anatomy Link Frequency
neurons 10
Ghrl (Mus musculus)
Ghrh (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 55 98.72 Very High Very High Very High
gABA 30 98.58 Very High Very High Very High
agonist 40 95.24 Very High Very High Very High
GABAergic 45 92.48 High High
antagonist 65 90.32 High High
Action potential 110 77.76 Quite High
Central nervous system 5 73.60 Quite High
Neuropeptide 15 61.36 Quite High
Calcium channel 45 37.08 Quite Low
TRP channel 5 33.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 30 99.32 Very High Very High Very High
Decapitation 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some mathematical models have incorporated an antagonistic effect of ghrelin on the hypothalamic effects of somatostatin [1], but this is not essential, since in the mouse, the stimulatory effect of ghrelin on GHRH neurons was observed in the absence of somatostatin.
ghrelin Regulation (effect) of Gene_expression (neurons) of GHRH in neurons associated with somatostatin
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.10
GABA also modulates GHRH neurons [27], so its potential involvement in the effect of ghrelin on GHRH neurons was studied.
ghrelin Regulation (effect) of Gene_expression (neurons) of GHRH in neurons associated with gaba
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.36
Here, we took advantage of GHRH-GFP transgenic mice [28] to investigate whether ghrelin modulates GHRH neurons.
ghrelin Spec (whether) Regulation (modulates) of Gene_expression (neurons) of GHRH in neurons associated with targeted disruption
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0.15 Pain Relevance 0.28
In contrast to this, other data suggest an indirect modulation of GHRH neurons by ghrelin.
ghrelin Regulation (modulation) of Gene_expression (neurons) of GHRH in neurons
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0.06 Pain Relevance 0.03
This direct modulation of GHRH neurons by ghrelin parallels the direct effect of ghrelin on NPY neurons, which orchestrates the activity of the appetite network [2].
ghrelin Regulation (modulation) of Gene_expression (neurons) of GHRH in neurons
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.18

General Comments

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