INT295541

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl, Ghrh) extracellular region (Ghrl, Ghrh) cytoplasm (Ghrl)
Anatomy Link Frequency
neurons 3
Ghrl (Mus musculus)
Ghrh (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 66 91.36 High High
antagonist 39 90.80 High High
agonist 24 80.72 Quite High
gABA 18 17.36 Low Low
Somatostatin 33 5.00 Very Low Very Low Very Low
GABAergic 27 5.00 Very Low Very Low Very Low
Calcium channel 27 5.00 Very Low Very Low Very Low
Neuropeptide 9 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, it is likely that GHSR activation mediates the enhancement of the electrical activity of GHRH neurons induced by ghrelin and the GHS tested in this study.
ghrelin Positive_regulation (induced) of GHRH in neurons
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.19
As summarized in Fig. 1E, ghrelin (10 nM) increased the electrical activity of all GHRH neurons tested from female GHRH-GFP mice (p<0.05 in the 0.75–6.25 Hz range, paired student's t-test), and did not change their firing pattern (data not shown).
ghrelin Positive_regulation (increased) of GHRH in neurons
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.08
Ghrelin directly activated GHRH neurons, and this modulation obviously concerns the GH axis, and does not require NPY neurons involved in feeding.
Ghrelin Positive_regulation (activated) of GHRH in neurons
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0

General Comments

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