INT295546

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.09
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ghsr) extracellular space (Ghrl) extracellular region (Ghrl)
plasma membrane (Ghsr) signal transducer activity (Ghsr) cytoplasm (Ghrl)
Anatomy Link Frequency
cell group 1
Ghrl (Mus musculus)
Ghsr (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 73 100.00 Very High Very High Very High
Ventral tegmentum 69 100.00 Very High Very High Very High
antagonist 57 87.60 High High
midbrain 2 81.84 Quite High
agonist 9 67.24 Quite High
cocaine 2 65.76 Quite High
alcohol 7 58.08 Quite High
Opioid 7 45.36 Quite Low
Glutamate 8 44.20 Quite Low
nMDA receptor antagonist 3 38.36 Quite Low
Disease Link Frequency Relevance Heat
Salivary Gland Disease 2 90.28 High High
Body Weight 3 28.32 Quite Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Polycystic Kidney Disease 2 5.00 Very Low Very Low Very Low
Hyperphagia 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Aids-related Complex 1 5.00 Very Low Very Low Very Low
Dysgeusia 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together with previous neuroanatomical and accumbal dopamine measurement studies showing that the target cells for ghrelin in the VTA include the dopaminergic cell group (Abizaid et al. 2006; Jerlhag et al. 2006; Jerlhag 2008; Kawahara et al. 2009; Quarta et al. 2009), it seems likely that peripheral ghrelin directly activates the VTA dopamine system via GHS-R1A.
ghrelin Positive_regulation (activates) of GHS-R1A in cell group associated with ventral tegmentum and dopamine
1) Confidence 0.39 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0 Pain Relevance 0.75
To activate the GHSR, ghrelin must be acylated with an eight-carbon fatty acid at serine 3 by ghrelin-O-acyltransferase (GOAT) [26], [27].
ghrelin Positive_regulation (activate) of GHSR
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.09 Pain Relevance 0
The canonical effector of GHSR is phospholipase C dependent [4], [6], but GHSR activation by ghrelin can elicit the activation of other pathways depending on the tissue context [37].
ghrelin Positive_regulation (activation) of GHSR
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.03

General Comments

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