INT295547

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.06
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl, Ghrh) extracellular region (Ghrl, Ghrh) cytoplasm (Ghrl)
Anatomy Link Frequency
neurons 6
Ghrl (Mus musculus)
Ghrh (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 48 98.94 Very High Very High Very High
gABA 36 98.72 Very High Very High Very High
Action potential 132 95.40 Very High Very High Very High
antagonist 78 92.96 High High
GABAergic 54 90.28 High High
Somatostatin 66 46.92 Quite Low
Neuropeptide 18 28.84 Quite Low
Calcium channel 54 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 56.64 Quite High
Decapitation 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GABA and NPY, two products of NPY neurons, were not involved in the effect of ghrelin on GHRH neurons (present study), and AgRP is thought to be ineffective on the GH axis, notably at the hypothalamic level [62].
ghrelin Regulation (effect) of GHRH in neurons associated with gaba
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.17
Importantly, while GHRH might have some properties of a GHSR agonist [59]–[61], mouse GHRH did not mimic the stimulatory effect of ghrelin on GHRH neurons (unpublished data).
ghrelin Regulation (effect) of GHRH in neurons associated with agonist
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.18
The effect of ghrelin on GHRH neurons in aged (>22 months-old) male GHRH-GFP mice was indeed present but heterogeneous, being stimulatory in only 8 out of 13 experiments (supporting Figure S2C–D).
ghrelin Regulation (effect) of GHRH in neurons
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.10
The signature of the neuromodulatory effect of ghrelin on GHRH neurons was further investigated with the perforated patch-clamp technique [49], where amplitudes and kinetics of action potentials can be quantified (as shown by the individual traces of Fig. 9A).
ghrelin Regulation (effect) of GHRH in neurons associated with action potential
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.24
In contrast to this, other data suggest an indirect modulation of GHRH neurons by ghrelin.
ghrelin Regulation (modulation) of GHRH in neurons
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0.06 Pain Relevance 0.03
This direct modulation of GHRH neurons by ghrelin parallels the direct effect of ghrelin on NPY neurons, which orchestrates the activity of the appetite network [2].
ghrelin Regulation (modulation) of GHRH in neurons
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.18

General Comments

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