INT29555

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Context Info
Confidence 0.69
First Reported 1985
Last Reported 2011
Negated 4
Speculated 0
Reported most in Body
Documents 58
Total Number 63
Disease Relevance 14.09
Pain Relevance 17.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
smooth muscle 1
internal 1
uterine 1
neck 1
neuronal 1
CALM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
complementary and alternative medicine 3727 100.00 Very High Very High Very High
Kinase C 69 100.00 Very High Very High Very High
pain labor 1 99.56 Very High Very High Very High
backache 20 99.48 Very High Very High Very High
Neurotransmitter 11 96.60 Very High Very High Very High
monoamine 4 95.88 Very High Very High Very High
Acupuncture 214 94.00 High High
Pain 167 90.24 High High
Inflammation 21 86.48 High High
biopsychosocial 4 82.40 Quite High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 64 99.88 Very High Very High Very High
Labor Pain 1 99.56 Very High Very High Very High
Chronic Fatigue Syndrome 259 99.52 Very High Very High Very High
Low Back Pain 28 99.48 Very High Very High Very High
Cancer 557 99.44 Very High Very High Very High
Diabetes Mellitus 377 98.92 Very High Very High Very High
Adhesions 15 98.92 Very High Very High Very High
Chronic Disease 70 98.88 Very High Very High Very High
Increased Venous Pressure Under Development 30 98.44 Very High Very High Very High
Mental Disorders 55 98.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogen increased the rat uterine calmodulin concentration, but progesterone did not change it.
Positive_regulation (increased) of calmodulin in uterine
1) Confidence 0.69 Published 1985 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 4024072 Disease Relevance 0.10 Pain Relevance 0.10
Reported trends for increasing CAM use within US adult populations underscore the importance of understanding CAM treatments and for including CAM in discussions of US healthcare policy and practice [11-15].
Positive_regulation (increasing) of CAM associated with complementary and alternative medicine
2) Confidence 0.61 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1884175 Disease Relevance 0 Pain Relevance 0.49
While one of these will predictably be a beneficial impact in its emphasis on outcomes rather than explanations [8], an outcome that will elevate CAM to the status of an accepted healthcare option, this paper indicates that this same benefit interpreted in a historical context will constitute a drawback for the development of some CAM modalities.
Positive_regulation (elevate) of CAM associated with complementary and alternative medicine
3) Confidence 0.59 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952302 Disease Relevance 0.09 Pain Relevance 0.49
The increase in CAM patronage and of constitutional claims to tax relief and reimbursement for CAM expenses has influenced debates about cost effectiveness, an index that has emerged as a crucial determinant of which CAM modality should obtain state funding.
Positive_regulation (increase) of CAM associated with complementary and alternative medicine
4) Confidence 0.59 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952302 Disease Relevance 0.08 Pain Relevance 0.51
These findings indicate that CAM is being sought for a small percentage of infants, although the reasons for such CAM use were not specified.
Positive_regulation (sought) of CAM associated with complementary and alternative medicine
5) Confidence 0.50 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2586313 Disease Relevance 0.34 Pain Relevance 0.91
This is consistent with a role of IP3 and calmodulin in the effects of these drugs.
Positive_regulation (role) of calmodulin
6) Confidence 0.48 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7774682 Disease Relevance 0 Pain Relevance 0.26
We conclude that spontaneous phasic contractions of human sigmoid circular smooth muscle may be mediated by activation of NK2 receptors, calcium release from intracellular stores, and activation of calmodulin and protein kinase C.
Positive_regulation (activation) of calmodulin in smooth muscle associated with kinase c
7) Confidence 0.48 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16554357 Disease Relevance 0.26 Pain Relevance 0.15
Increasing the Ca2+/calmodulin activity of loperamide-pretreated BBMVs with 2 microM calcium plus 5 microM calmodulin led to a significant inhibition of Cl-/OH- antiport and Na+/Cl- cotransport by 40% +/- 5% (p less than 0.005).
Positive_regulation (Increasing) of calmodulin
8) Confidence 0.45 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2836258 Disease Relevance 0 Pain Relevance 0
The prevalence of CAM use was 22.7% before and 61.0% after diagnosis with Type 2 diabetes with nutritional supplements being the most commonly used CAM before and after diagnosis.
Positive_regulation (used) of CAM associated with diabetes mellitus
9) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952338 Disease Relevance 0.55 Pain Relevance 0
The third section of the survey, based on a review of Taiwanese and English language literature, focused on patterns of CAM use including: the reasons for CAM use, factors influencing the decision to use CAM, the administration of CAM with conventional treatments, the disclosure of CAM use to healthcare professionals, and the reasons for not using CAM or ceasing CAM.
Positive_regulation (use) of CAM
10) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952338 Disease Relevance 0.16 Pain Relevance 0
The high level of CAM use concomitantly with conventional medicines found in this study confirms that patients do not use CAM to replace conventional medicine but rather to complement it.
Neg (not) Positive_regulation (use) of CAM
11) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952338 Disease Relevance 0.18 Pain Relevance 0.07
Of the 326 participants, 22.7% (n = 74) reported using CAM before diagnosis, with the number of patients using CAM increasing to 61.0% (n = 199) after diagnosis.
Positive_regulation (using) of CAM
12) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952338 Disease Relevance 0.40 Pain Relevance 0
The third section of the survey, based on a review of Taiwanese and English language literature, focused on patterns of CAM use including: the reasons for CAM use, factors influencing the decision to use CAM, the administration of CAM with conventional treatments, the disclosure of CAM use to healthcare professionals, and the reasons for not using CAM or ceasing CAM.
Positive_regulation (using) of CAM
13) Confidence 0.44 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952338 Disease Relevance 0.16 Pain Relevance 0
We present three cases of head and neck cancer patients; two used complementary and alternative medicine (CAM) prior to presenting to our service and the third declined conventional treatment to seek CAM instead.
Positive_regulation (seek) of CAM in neck associated with complementary and alternative medicine and head & neck cancer
14) Confidence 0.44 Published 2008 Journal Ir Med J Section Abstract Doc Link 18540546 Disease Relevance 0.35 Pain Relevance 0.29
The advent of practice based commissioning signals a new route by which patients may increasingly access CAM within UK primary care [6].
Positive_regulation (access) of CAM associated with complementary and alternative medicine
15) Confidence 0.44 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1896178 Disease Relevance 0 Pain Relevance 0.49
• Hierarchy of acceptability of CAM and the nature of evidence

• The role of CAM within the NHS.

Positive_regulation (acceptability) of CAM associated with complementary and alternative medicine
16) Confidence 0.44 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1896178 Disease Relevance 0 Pain Relevance 0.51
These included lectures to and electives for medical students, rotations for internal medicine residents, and a survey course where medical students learn about and experience CAM therapies.
Positive_regulation (experience) of CAM in internal associated with complementary and alternative medicine
17) Confidence 0.44 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC1343546 Disease Relevance 0.07 Pain Relevance 0.17
Some people use CAM as a complement to their regular medical care, either to improve general health and wellness or as an adjunct to treatment for chronic illnesses like back pain [4].
Positive_regulation (use) of CAM associated with complementary and alternative medicine, chronic disease and backache
18) Confidence 0.43 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266896 Disease Relevance 0.19 Pain Relevance 0.51
Others prefer CAM as an alternative to mainstream medicine, citing dissatisfaction with mainstream medicine as their primary reason for use [4].
Positive_regulation (prefer) of CAM associated with complementary and alternative medicine
19) Confidence 0.43 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266896 Disease Relevance 0.32 Pain Relevance 0.53
Whatever the reason for its use, many of those who use CAM in addition to conventional medical care do not report CAM use to their primary care physician [3,5].
Positive_regulation (use) of CAM associated with complementary and alternative medicine
20) Confidence 0.43 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266896 Disease Relevance 0.55 Pain Relevance 0.48

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