INT295552

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 1.64
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ghsr) extracellular space (Ghrl) extracellular region (Ghrl)
plasma membrane (Ghsr) signal transducer activity (Ghsr) cytoplasm (Ghrl)
Anatomy Link Frequency
arcuate nucleus 3
stomach 2
adipocyte 1
Ghrl (Mus musculus)
Ghsr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 96 99.04 Very High Very High Very High
Serotonin 12 98.80 Very High Very High Very High
adenocard 3 97.36 Very High Very High Very High
midbrain 3 90.00 High High
Ventral tegmentum 3 87.04 High High
Opioid 5 82.72 Quite High
Somatostatin 42 80.20 Quite High
Neuropeptide 9 75.80 Quite High
Nucleus accumbens 3 71.04 Quite High
agonist 21 68.16 Quite High
Disease Link Frequency Relevance Heat
Obesity 245 99.12 Very High Very High Very High
Aids-related Complex 3 96.44 Very High Very High Very High
Reprotox - General 1 5 89.00 High High
Hyperinsulinism 50 80.16 Quite High
Salivary Gland Disease 6 78.00 Quite High
Diabetes Mellitus 150 69.32 Quite High
Disease 30 67.44 Quite High
Body Weight 48 57.00 Quite High
Hypoglycemia 10 29.64 Quite Low
Polycystic Kidney Disease 6 23.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ghrelin binds to the GHSR to promote foraging and feeding behaviors, mainly via the hypothalamic arcuate nucleus (ARC).
Ghrelin Binding (binds) of GHSR in arcuate nucleus associated with aids-related complex
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.10 Pain Relevance 0.35
Ghrelin, a 28-amino-acid peptide, is an orexigenic hormone that was first isolated from X/A cells in the stomach [20] and is a ligand for the growth hormone secretagogue receptor (GHSR) [21].
Ghrelin Binding (ligand) of secretagogue receptor in stomach
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.13 Pain Relevance 0.05
Ghrelin, a 28-amino-acid peptide, is an orexigenic hormone that was first isolated from X/A cells in the stomach [20] and is a ligand for the growth hormone secretagogue receptor (GHSR) [21].
Ghrelin Binding (ligand) of GHSR in stomach
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.14 Pain Relevance 0.05
Like ghrelin, they exhibit a nanomolar affinity for GHSR, the canonical ghrelin receptor of the GH axis found in the arcuate nucleus [3], [4].
ghrelin Binding (affinity) of ghrelin receptor in arcuate nucleus
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.06
Like ghrelin, they exhibit a nanomolar affinity for GHSR, the canonical ghrelin receptor of the GH axis found in the arcuate nucleus [3], [4].
ghrelin Binding (affinity) of GHSR in arcuate nucleus
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.06
Evidences that UAG is an active peptide implies the existence of GHSR subtypes that recognize and bind ghrelin independently of its acylation.
ghrelin Binding (recognize) of GHSR
6) Confidence 0.19 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.08 Pain Relevance 0.04
These effects of UAG could not be antagonized by administration of synthetic GHSR1a antagonists [28] as UAG is unable to bind the classical GHSR1a, which recognizes ghrelin in its acylated form only [9].
ghrelin Binding (recognizes) of GHSR1a associated with antagonist
7) Confidence 0.19 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.09 Pain Relevance 0.05
In 1999, ghrelin was identified as the endogenous ligand for the GHSR.
ghrelin Binding (ligand) of GHSR
8) Confidence 0.17 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.14 Pain Relevance 0.16
Evidences that UAG is an active peptide implies the existence of GHSR subtypes that recognize and bind ghrelin independently of its acylation.
ghrelin Binding (bind) of GHSR
9) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.08 Pain Relevance 0.04
Interestingly, ghrelin did not affect insulin-stimulated glucose uptake in perirenal adipocytes, which do not express GHSR1a, and des-acyl ghrelin, which does not bind to GHSR1a, did not influence insulin-stimulated glucose uptake in epididymal adipocytes The effects of ghrelin on adipocyte glucose uptake might be expected to result in fatty acid accumulation and an increase in adiposity in the long term [145].
ghrelin Neg (not) Spec (might) Binding (bind) of GHSR1a in adipocyte associated with obesity
10) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.89 Pain Relevance 0

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