INT29557

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Context Info
Confidence 0.57
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 6.78
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (MIA3)
Anatomy Link Frequency
blood 1
plasma 1
fat 1
B-cell 1
lymphocytes 1
MIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 19 99.54 Very High Very High Very High
opioid receptor 3 98.40 Very High Very High Very High
Endogenous opioid 1 98.28 Very High Very High Very High
tolerance 34 94.16 High High
Opioid 2 91.76 High High
antagonist 4 91.48 High High
Bile 1 90.24 High High
Chronic pancreatitis 10 81.60 Quite High
headache 3 80.60 Quite High
cytokine 27 79.60 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 569 99.56 Very High Very High Very High
Obesity 22 98.46 Very High Very High Very High
Disease Progression 3 97.88 Very High Very High Very High
Cancer 12 96.88 Very High Very High Very High
Impaired Glucose Tolerance 13 94.48 High High
Body Weight 10 93.84 High High
Insulin Resistance 35 93.68 High High
Pancreatitis 14 87.64 High High
Epstein-barr Virus 3 87.12 High High
Stress 25 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation by hCRF of C-peptide release in type 2 diabetics during concomitant opioid receptor blockade.
Localization (release) of C-peptide associated with diabetes mellitus, narcan and opioid receptor
1) Confidence 0.57 Published 1988 Journal Klin. Wochenschr. Section Title Doc Link 2836651 Disease Relevance 0.28 Pain Relevance 0.42
Naloxone modulates gustatory perception, but not insulin and C-peptide release, in sham-fed human subjects.
Localization (release) of C-peptide associated with narcan
2) Confidence 0.54 Published 1986 Journal Int J Obes Section Title Doc Link 3522452 Disease Relevance 0 Pain Relevance 0.28
After P-JS, the integrated blood glucose value decreased (P<.02), but there was no change in integrated serum C-peptide secretion.
Localization (secretion) of C-peptide in blood
3) Confidence 0.38 Published 2004 Journal Surgery Section Body Doc Link 14739846 Disease Relevance 0 Pain Relevance 0
Endpoints were exocrine function (fecal fat excretion, urinary PABA recovery), endocrine function (oral glucose tolerance test, serum C-peptide concentrations), and pancreatic polypeptide secretion.
Localization (secretion) of C-peptide in fat
4) Confidence 0.33 Published 2004 Journal Surgery Section Body Doc Link 14739846 Disease Relevance 0.07 Pain Relevance 0
Serum insulin and C-peptide were measured by RIA (Schering GmbH, Berlin, Germany).
Localization (measured) of C-peptide
5) Confidence 0.10 Published 2010 Journal The British Journal of Nutrition Section Body Doc Link PMC2943747 Disease Relevance 0.17 Pain Relevance 0
colocalisation of C-peptide with intimal monocyte/macrophages and CD4+ lymphocytes in some of the diabetic
Localization (colocalisation) of C-peptide in lymphocytes associated with diabetes mellitus
6) Confidence 0.07 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.88 Pain Relevance 0
Since C-peptide also colocalized
Localization (colocalized) of C-peptide
7) Confidence 0.07 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.68 Pain Relevance 0
proatherogenic effect of C-peptide.

5.

Localization (effect) of C-peptide
8) Confidence 0.07 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.62 Pain Relevance 0
The DCCT showed that intensive insulin therapy helps sustain endogenous insulin secretion (with stimulated C-peptide levels above the clinically relevant value of 0.2 pmol/ml), suggesting that continuous insulin administration and its glucose-lowering effect is potentially beneficial for B-cell preservation [56].
Localization (secretion) of C-peptide in B-cell
9) Confidence 0.07 Published 2008 Journal Diabetic Medicine Section Body Doc Link PMC2701557 Disease Relevance 0.56 Pain Relevance 0.06
But it should be noted that C-peptide secretion was maintained in 80% of the patients up to 5 years post-islet transplantation and that the hypoglycaemic score, lability index and HbA1c improved significantly in those who retained detectable C-peptide.
Localization (secretion) of C-peptide
10) Confidence 0.06 Published 2008 Journal Diabetic Medicine Section Body Doc Link PMC2701557 Disease Relevance 0.36 Pain Relevance 0
It should be noted that, in spite of the overall initial efficacy in prevention of disease progression, the effects of the therapy varied between individuals (with some patients failing to recover endogenous C-peptide secretion from the beginning of the treatment) and eventually the decline of insulin production was inevitable.
Localization (secretion) of C-peptide associated with disease progression
11) Confidence 0.06 Published 2008 Journal Diabetic Medicine Section Body Doc Link PMC2701557 Disease Relevance 0.60 Pain Relevance 0.21
Mean pretransplant serum C-peptide levels of 0.1?
Localization (pretransplant) of C-peptide
12) Confidence 0.05 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.23 Pain Relevance 0.03
Thus, IPCs respond to glucose challenge in vivo by releasing insulin C-peptide.
Localization (releasing) of C-peptide
13) Confidence 0.05 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.21 Pain Relevance 0
Following transplantation into immunocompromised mice, IPCs released insulin C-peptide upon glucose challenge, remained differentiated, and did not form detectable tumors.


Localization (released) of C-peptide associated with cancer
14) Confidence 0.04 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC1087208 Disease Relevance 0.17 Pain Relevance 0
From 106 cells at stage 2, we produced an average of 200–400 clusters with approximately 2,000 cells per cluster; approximately 25% of these cells are C-peptide+ and release 0.5%–1% of C-peptide secreted by ?
Localization (secreted) of C-peptide
15) Confidence 0.04 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.05 Pain Relevance 0
During the follow-up period, persistent C-peptide secretion was evident.
Localization (secretion) of C-peptide
16) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551676 Disease Relevance 0.06 Pain Relevance 0
In order to investigate the relationships between glucose metabolism, insulin secretion and endogenous opioids in obese patients, we have studied the effects of a naloxone infusion on insulin and C-peptide release after a normal meal (800 kcal) eaten at 12.00 hr in 16 obese women, aged 20-61 yr, with a BMI ranging from 25 to 37.2 kg/m2, with normal glucose tolerance (Group 1) and with NIDDM (Group 2).
Localization (release) of C-peptide associated with diabetes mellitus, obesity, tolerance, narcan, endogenous opioid and impaired glucose tolerance
17) Confidence 0.02 Published 1993 Journal Diabetes Res. Section Abstract Doc Link 7712683 Disease Relevance 0.46 Pain Relevance 0.37
Insulin and C-peptide are stored in the mature secretory granules and secreted in equimolar amounts [22].
Localization (secreted) of C-peptide
18) Confidence 0.02 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 0.35 Pain Relevance 0.03
RESULTS: Glucagon and C-peptide secretions after arginine stimulation were reduced in patients with moderate and severe chronic pancreatitis while no parameter was able to show impaired endocrine function in the early stage (ERP I) of the disease.
Localization (secretions) of C-peptide
19) Confidence 0.02 Published 1998 Journal Hepatogastroenterology Section Body Doc Link 9756016 Disease Relevance 0.14 Pain Relevance 0
The endocrine parameters correlated linearly with the exocrine ones, most markedly C-peptide reserve with pancreatic enzyme secretion.
Localization (secretion) of C-peptide
20) Confidence 0.01 Published 1985 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 3881238 Disease Relevance 0.25 Pain Relevance 0.20

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