INT29558

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Context Info
Confidence 0.32
First Reported 1988
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 2.33
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
Anatomy Link Frequency
plasma 4
lung 2
polymorphonuclear leukocyte 2
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 33 100.00 Very High Very High Very High
Enkephalin 7 99.98 Very High Very High Very High
chemokine 1 81.48 Quite High
tolerance 57 75.24 Quite High
Inflammation 114 66.16 Quite High
abdominal pain 1 64.64 Quite High
headache 1 64.00 Quite High
Potency 16 61.20 Quite High
Bioavailability 3 58.20 Quite High
Inflammatory mediators 13 56.04 Quite High
Disease Link Frequency Relevance Heat
Hyperoxia 23 99.98 Very High Very High Very High
Stress 55 98.04 Very High Very High Very High
Hemorrhagic Shock 32 97.42 Very High Very High Very High
Hypertension 4 87.72 High High
Urological Neuroanatomy 9 80.40 Quite High
American Trypanosomiasis 1 80.28 Quite High
Bronchopulmonary Dysplasia 15 73.44 Quite High
Bacterial Respiratory Disease 1 71.80 Quite High
Pneumonia 16 66.56 Quite High
Vomiting 1 65.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to these authors, S100 proteins interact directly with flavocytochrome b558 and mediate its transition from an inactive to an active conformation state, resulting in NADPH oxidase activation.
Positive_regulation (mediate) of Positive_regulation (activation) of NADPH oxidase
1) Confidence 0.32 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Although the precise nature of [Ca2+]c elevation in fMLF-induced NADPH oxidase activation has not been resolved conclusively, evidence, based on the use of pharmalogical blockers of SOCE, exists to support a role of SOCE in the oxidative response.
Positive_regulation (induced) of Positive_regulation (activation) of NADPH oxidase
2) Confidence 0.32 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.08
Although the precise nature of [Ca2+]c elevation in fMLF-induced NADPH oxidase activation has not been resolved conclusively, evidence, based on the use of pharmalogical blockers of SOCE, exists to support a role of SOCE in the oxidative response.
Positive_regulation (elevation) of Positive_regulation (activation) of NADPH oxidase
3) Confidence 0.32 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.08
Evidence for the requirement of extracellular Ca2+ entry for NADPH oxidase activation is supported by a significant decrease of superoxide anion production when extracellular Ca2+ is suppressed or chelated by EGTA [3, 8, 9].
Positive_regulation (requirement) of Positive_regulation (activation) of NADPH oxidase
4) Confidence 0.32 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Strong evidence for Ca2+ dependence of NADPH oxidase activation came from deprivation of extracellular Ca2+ and depletion of intracellular Ca2+ stores [34567].
Positive_regulation (dependence) of Positive_regulation (activation) of NADPH oxidase associated with addiction
5) Confidence 0.32 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.05
An increase of [Ca2+]c is accordingly not sufficient to initiate NADPH oxidase activation in the plasma membrane; an additionnal signal in combination with Ca2+ influx is almost certainly required for NADPH oxidase activation [3].


Positive_regulation (required) of Positive_regulation (activation) of NADPH oxidase in plasma
6) Confidence 0.30 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
These findings confirm that Ca2+ uptake via SOCE is required for NADPH oxidase activation.
Positive_regulation (required) of Positive_regulation (activation) of NADPH oxidase
7) Confidence 0.30 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.08
S100A8/S100A9 complexes facilitate NADPH oxidase activation by transferring arachidonic acid to the NADPH oxidase complex [159].
Positive_regulation (facilitate) of Positive_regulation (activation) of NADPH oxidase
8) Confidence 0.30 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
An increase of [Ca2+]c is accordingly not sufficient to initiate NADPH oxidase activation in the plasma membrane; an additionnal signal in combination with Ca2+ influx is almost certainly required for NADPH oxidase activation [3].


Neg (not) Positive_regulation (sufficient) of Positive_regulation (activation) of NADPH oxidase in plasma
9) Confidence 0.30 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
A recent study demonstrated that [Ca2+]c elevation triggers a conformational change in the Nox5 N terminus, leading to NADPH oxidase activation through an interaction between the regulatory N terminus and C terminal catalytic domain [147].
Positive_regulation (leading) of Positive_regulation (activation) of NADPH oxidase
10) Confidence 0.30 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Therefore, it has to be concluded that common agents used for activation (fMLF, opsonized zymosan) trigger different signaling pathways, resulting in NADPH oxidase activation.


Positive_regulation (resulting) of Positive_regulation (activation) of NADPH oxidase
11) Confidence 0.30 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.06 Pain Relevance 0.03
In comparative studies of f-met-Leu-Phe (FMLP) and methionine enkephalin (ME) induced polymorphonuclear leukocyte (PMNL) stimulation the following results were obtained: (i) both FMLP and ME increased the intracellular killing (IK) capability of human PMNLs probably through NADPH oxidase activation, (ii) the ME-induced respiratory burst (RB) differed from the chemotactic peptide FMLP-triggered superoxide generation because the former was not accompanied by the activation of the glutathione system and the duration of the superoxide production was prolonged.
Positive_regulation (increased) of Positive_regulation (activation) of NADPH oxidase in polymorphonuclear leukocyte associated with enkephalin
12) Confidence 0.28 Published 1988 Journal Life Sci. Section Abstract Doc Link 2836681 Disease Relevance 0 Pain Relevance 0.53
These findings indicate that the inhibitory effects of evodiamine and rutaecarpine on LIGHT-induced migration and the activation of CCR1, CCR2, ICAM-1, ERK, and p38 MAPK occurs via decreased ROS production and NADPH oxidase activation.
Positive_regulation (occurs) of Positive_regulation (activation) of NADPH oxidase
13) Confidence 0.11 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19241441 Disease Relevance 0.25 Pain Relevance 0.17
We have reported that in HS, HMGB1 through TLR4 signaling upregulates TLR2 in ECs, and this upregulation associates with an amplified EC function including augmented activation of NADPH oxidase and expression of ICAM-1 in response to TLR2 activation by HMGB1 [48].
Positive_regulation (augmented) of Positive_regulation (activation) of NADPH oxidase associated with hemorrhagic shock
14) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.71 Pain Relevance 0.09
In the present study, increased expression of the p67phox protein was observed both in the cytosolic and membrane fraction in HC, and G-CSF treatment significantly attenuated hyperoxia-induced NADPH oxidase activation as evidenced by reduced membrane translocation of the p67phox in the lung tissue.
Positive_regulation (induced) of Positive_regulation (activation) of NADPH oxidase in lung associated with hyperoxia
15) Confidence 0.01 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.80 Pain Relevance 0.03
For ISDN, increased activation of NADPH oxidase was demonstrated in experimental MI as well as the adverse effects of the nitrate on the function of endothelial progenitor cells [90] although previous work by Keimer et al. revealed no induction of oxidative stress under ISDN or PETN therapy in healthy volunteers [91].
Positive_regulation (increased) of Positive_regulation (activation) of NADPH oxidase associated with stress
16) Confidence 0.01 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014692 Disease Relevance 0.52 Pain Relevance 0.13

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