INT29561

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Context Info
Confidence 0.48
First Reported 1988
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 25.86
Pain Relevance 6.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTM1) small molecule metabolic process (GSTM1) cytoplasm (GSTM1)
Anatomy Link Frequency
coronary artery 1
thalamus 1
ASK 1
GSTM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 48 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
Opioid receptor 1 2 100.00 Very High Very High Very High
agonist 4 99.98 Very High Very High Very High
Inflammatory response 25 99.76 Very High Very High Very High
Inflammation 186 99.60 Very High Very High Very High
Pain 16 99.46 Very High Very High Very High
Dismenorea 32 99.16 Very High Very High Very High
Thalamus 1 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 757 100.00 Very High Very High Very High
Coronary Artery Disease 338 100.00 Very High Very High Very High
Endometriosis (extended) 54 100.00 Very High Very High Very High
INFLAMMATION 232 99.76 Very High Very High Very High
Pain 14 99.46 Very High Very High Very High
Reprotox - General 1 27 99.16 Very High Very High Very High
Myocardial Infarction 19 98.96 Very High Very High Very High
Cancer 151 98.60 Very High Very High Very High
Diabetes Mellitus 99 98.56 Very High Very High Very High
Apoptosis 27 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Larger studies are warranted to investigate potential interaction between GSTM1 null and phthalate exposure in the etiology of estrogen-dependent gynecologic conditions.


GSTM1 Binding (interaction) of
1) Confidence 0.48 Published 2010 Journal Hum. Reprod. Section Body Doc Link 20147336 Disease Relevance 0 Pain Relevance 0
There was no effect of interaction of GSTM1 genotype and smoking on CAD development between group B and C (Table 3).
GSTM1 Neg (no) Binding (interaction) of associated with coronary artery disease and nicotine addiction
2) Confidence 0.48 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.89 Pain Relevance 0
An interaction between GSTM1 genotypes and benzo [a]pyrene DNA adducts through air pollution in urban and rural areas was investigated in 120 healthy non-smoking residents indicating that the deletion of the GSTM1 gene may be an important step in the early onset of diseases [40].
GSTM1 Binding (interaction) of associated with nicotine addiction and disease
3) Confidence 0.48 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.19 Pain Relevance 0
The previous study by Ryberg and coworkers support the interaction between GSTM1 and GSTP1 genetic polymorphisms (30).
GSTM1 Binding (interaction) of
4) Confidence 0.48 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.82 Pain Relevance 0.20
This result suggests that there are interactions between GSTM1 and GSTP1 genetic polymorphisms, thus subjects with the combination of GSTM1 null and GSTP1 AG or GG genotypes are more susceptible to smoking-induced inflammation than those with the other genotype combinations.
GSTM1 Binding (interactions) of associated with nicotine addiction and inflammation
5) Confidence 0.48 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.99 Pain Relevance 0.19
In marked distinction to all other kappa-active agents examined which typically compete mu1 binding with Ki values under 1 nM, U50,488 competed mu1 binding quite poorly (Ki 370 nM).
mu1 Binding (binding) of
6) Confidence 0.47 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 2836756 Disease Relevance 0 Pain Relevance 0.16
Considering the synergistic effects of GSTM1 null genotype and GSTT1 null genotype on risk of smoking-related CAD, we found that smokers with both GSTM1 and GSTT1 null genotype were at an approximately 2.76-fold higher risk of CAD than nonsmokers with both GSTM1 and GSTT1 positive genotype (CI, 1.17-6.52, p=0.04)
GSTM1 Binding (smokers) of associated with coronary artery disease and nicotine addiction
7) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.36 Pain Relevance 0
Considering the synergistic effects of GSTM1 null genotype and GSTT1 null genotype on risk of smoking-related CAD, we found that smokers with both GSTM1 and GSTT1 null genotype were at an approximately 2.76-fold higher risk of CAD than nonsmokers with both GSTM1 and GSTT1 positive genotype (CI, 1.17-6.52, p=0.04)
GSTM1 Binding (nonsmokers) of associated with coronary artery disease and nicotine addiction
8) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.35 Pain Relevance 0
The effect of interaction of GSTT1 gene and smoking on CAD risk, we found the similar results as those in GSTM1 gene.
GSTM1 Binding (interaction) of associated with coronary artery disease and nicotine addiction
9) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.14 Pain Relevance 0
The association between the concentrations of PCBs, GSTM1 null genotype and different severity of endometriosis was significant (P<0.05) for all four compounds and GSTM1 (PCB1: r = +0.5388, P<0.0001; PCB5: r = +0.6753, P<0.0001; PCB29: r = +0.6471, P<0.0001; and PCB98: r = +0.4357, P<0.0001; GSTM1: r = +0.9439, P = 0.05).
GSTM1 Binding (compounds) of
10) Confidence 0.37 Published 2009 Journal Indian J. Med. Res. Section Body Doc Link 19535834 Disease Relevance 0.06 Pain Relevance 0
Table 3 also shows the association of NAT2, GSTM1, GSTT1, and GSTP1 genotypes with chemical-related sensitivity scores (?
GSTM1 Binding (association) of
11) Confidence 0.37 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.22 Pain Relevance 0
The present study showed that subjects with the combination of GSTM1 null and GSTP1 AG or GG genotypes have higher TNF-?
GSTM1 Binding (combination) of
12) Confidence 0.37 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 1.11 Pain Relevance 0.22
The aims of this study were to investigate whether tobacco smoke exposure increases the level of inflammation biomarkers and the GSTM1 and GSTP1 gene polymorphisms are associated with inflammatory response due to tobacco smoke exposure.
GSTM1 Binding (associated) of associated with inflammatory response, nicotine addiction and inflammation
13) Confidence 0.37 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721922 Disease Relevance 1.10 Pain Relevance 0.22
Therefore, in the present study we tried to investigate whether tobacco smoke exposure increases the level of inflammation biomarkers and the GSTM1 and GSTP1 gene polymorphisms are associated with inflammatory response due to tobacco smoke exposure.


GSTM1 Binding (associated) of associated with inflammatory response, nicotine addiction and inflammation
14) Confidence 0.37 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 1.18 Pain Relevance 0.37
CONCLUSION: The results of this study indicate that deficient metabolism because of mutated CYP2D6 alleles or GSTM1 allele variants is not important in the aetiology of migraine.


GSTM1 Binding (metabolism) of
15) Confidence 0.37 Published 2000 Journal Eur. J. Clin. Invest. Section Body Doc Link 10759887 Disease Relevance 0.07 Pain Relevance 0
Epidemiological studies have indicated that GSTM1 and GSTT1 polymorphisms are associated with increased risk for different cancers among smokers, but there are still some controversies about the relationship between GST polymorphism and CAD in smokers (7, 17).
GSTM1 Binding (associated) of associated with coronary artery disease, nicotine addiction and cancer
16) Confidence 0.36 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.46 Pain Relevance 0.03
GSTM1 is a phase II enzyme that can scavenge oxygen free radicals, metabolize reactive oxygen species, and detoxify xenobiotics present in PM.
GSTM1 Binding (metabolize) of
17) Confidence 0.36 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.98 Pain Relevance 0.07
Genotypes associated with reduced or absent activity for GSTM1, GSTT1, and GSTA1 were not associated with increased toxicity.
GSTM1 Neg (absent) Binding (activity) of associated with toxicity
18) Confidence 0.35 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.44 Pain Relevance 0.03
The association of the GSTT1 and GSTM1 null-genotypes with coronary artery disease (CAD) among smokers has been the subject of many investigations [5-12], but to our knowledge no such studies have been conducted among Arabs.
GSTM1 Binding (association) of in coronary artery associated with nicotine addiction and coronary artery disease
19) Confidence 0.35 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.12 Pain Relevance 0
We admit that both presented functional explanations of our findings, i.e. interaction with cell signaling factors and competition on glutathione as substrate for both GST-P1 and GST-M1, remain theoretical ones.
GST-P1 Binding (interaction) of
20) Confidence 0.35 Published 2007 Journal J Transl Med Section Body Doc Link PMC2245909 Disease Relevance 0.65 Pain Relevance 0

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