INT29566

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Context Info
Confidence 0.46
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 8.04
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bpifa2) extracellular region (Bpifa2) biological_process (Bpifa2)
Anatomy Link Frequency
PSP 12
T cells 2
fat 1
spike 1
bowel 1
Bpifa2 (Mus musculus)
Pain Link Frequency Relevance Heat
Piles 26 99.88 Very High Very High Very High
cytokine 131 99.70 Very High Very High Very High
Action potential 20 96.96 Very High Very High Very High
Bile 65 94.12 High High
Inflammation 59 93.88 High High
metalloproteinase 10 91.32 High High
depression 117 89.44 High High
long-term potentiation 40 87.88 High High
tetrodotoxin 6 79.28 Quite High
addiction 53 77.36 Quite High
Disease Link Frequency Relevance Heat
Shellfish Poisoning 17 100.00 Very High Very High Very High
Anorectal Disorders 26 99.88 Very High Very High Very High
Anaphylaxis 6 99.28 Very High Very High Very High
Sprains And Strains 204 98.56 Very High Very High Very High
Pneumonia 117 98.42 Very High Very High Very High
Necrosis 6 94.04 High High
INFLAMMATION 61 93.88 High High
Cancer 9 93.68 High High
Corneal Neovascularization 78 93.08 High High
Hemorrhage 9 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On renal function in rats, T-1982 caused an increase of PSP excretion but had no effect on urine volume or electrolytes excretion at intravenous doses of 250--1,000 mg/kg.
Positive_regulation (increase) of PSP in urine
1) Confidence 0.46 Published 1982 Journal Jpn J Antibiot Section Abstract Doc Link 7143714 Disease Relevance 0.25 Pain Relevance 0.24
From December 2007 to April 2009 all patients with an external rectal prolapse were evaluated for PSP.
Positive_regulation (evaluated) of PSP in PSP associated with piles
2) Confidence 0.40 Published 2010 Journal BMC Surg Section Body Doc Link PMC2843648 Disease Relevance 0.40 Pain Relevance 0.05
Then the patients underwent PSP with no bowel preparation.
Neg (no) Positive_regulation (underwent) of PSP in bowel
3) Confidence 0.37 Published 2010 Journal BMC Surg Section Body Doc Link PMC2843648 Disease Relevance 0.31 Pain Relevance 0.04
Indirect responses: Application of ACh to adjacent cells caused an increase in postsynaptic potential (PSP) activity which was excitatory in 66% (38/58) and inhibitory in 17% (10/58).
Positive_regulation (increase) of PSP in PSP
4) Confidence 0.34 Published 1988 Journal Brain Res. Section Abstract Doc Link 2837312 Disease Relevance 0 Pain Relevance 0.21
However, the NIH mice immunized with a high concentration of both OVA and PSP were lost due to anaphylactic shock after the booster injection.
Positive_regulation (concentration) of PSP in PSP associated with anaphylaxis
5) Confidence 0.27 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.92 Pain Relevance 0.08
were significantly repressed in PSP-treated corneas compared to control corneas whereas the anti-angiogenic factor, PEDF, was upregulated in PSP-treated corneas when compared to the control corneas (Figure 5).
Positive_regulation (upregulated) of PSP in corneas
6) Confidence 0.18 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2751803 Disease Relevance 0.64 Pain Relevance 0.22
Furthermore, PSP also decreased the levels of activated AKT and ERK 1/2.


Positive_regulation (activated) of PSP in PSP
7) Confidence 0.17 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2751803 Disease Relevance 0.74 Pain Relevance 0.13
In marine waters, PSP is caused by toxic dinoflagellates, where STXs are produced by more temperate Alexandrium species and Gymnodinium catenatum and by tropical Pyrodinium bahamense var. compressum (Kao 1993).
Positive_regulation (caused) of PSP in PSP associated with shellfish poisoning
8) Confidence 0.10 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1626430 Disease Relevance 0.63 Pain Relevance 0
E [3],[55],[56], a drop of the proton motive force activates Psp [6], and accumulation of P-Pili subunits activates Cpx [13]; in the case of Rcs and Bae, specific signal sensing mechanisms remain to be identified.
Positive_regulation (activates) of Psp
9) Confidence 0.09 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2731931 Disease Relevance 0.30 Pain Relevance 0
Dibucaine activated the Cpx, Rcs, Bae, and Psp systems whereas 0.6 M NaCl activated only the Rcs and Psp pathways.
Positive_regulation (activated) of Psp
10) Confidence 0.06 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2731931 Disease Relevance 0.12 Pain Relevance 0
The recordings shown in Figures 1 and 15 show the result of somatic spiking summed with a compound PSP generated by synaptic conductances across the dendritic tree.
Positive_regulation (generated) of PSP in PSP
11) Confidence 0.06 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2924322 Disease Relevance 0 Pain Relevance 0
The entire sequence of PspA was used to predict the protein structure as well as ?
Positive_regulation (sequence) of PspA
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.42 Pain Relevance 0
While cells from naïve mice did not significantly respond to PspA peptides, CD4+ T lymphocytes from S. pneumonia strain EF3030-challenged mice also significantly secreted IL-4 and IL-5 after PspA peptide ex vivo stimulation (Figures 6 and 7).
Positive_regulation (stimulation) of PspA in T lymphocytes associated with pneumonia and sprains and strains
13) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.73 Pain Relevance 0.04
CD4+ T cells isolated from the spleen and CLNs also significantly secreted Th2 cytokines after ex vivo stimulation of PspA peptides, than compared to naïve mice.
Positive_regulation (stimulation) of PspA in T cells associated with cytokine
14) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.95 Pain Relevance 0.12
Feeding the high fat diet increased the urinary excretion of PSP and Cr-EDTA, indicators of intestinal permeability, in both LETO and OLETF rats at 3, 9, and 15 weeks after the onset of feeding.
Positive_regulation (increased) of PSP in fat
15) Confidence 0.01 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 1.02 Pain Relevance 0.08
The first spike led the PSP by 50 milliseconds.
Positive_regulation (led) of PSP in spike
16) Confidence 0.01 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2832108 Disease Relevance 0.23 Pain Relevance 0.12
Also in thalamocortical PSPs the facilitating effect of the up state still remains 200 ms into the down state, with an average amplitude increase of twice the PSP amplitude in the down state.
Positive_regulation (increase) of PSP in PSP
17) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0.09 Pain Relevance 0.04
As it has been described for the in vitro situation, no enhancement of the first PSP was observed when synaptic potentials occured during fake up states (data not shown).
Neg (no) Positive_regulation (enhancement) of PSP in PSP
18) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0 Pain Relevance 0.14
PSPs in active slices showed larger paired pulse facilitation, with an average increase of the second PSP with respect to the first one of 1.8 times (n?
Positive_regulation (increase) of PSP in PSP
19) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0 Pain Relevance 0
0.04) between the standard deviation of the membrane potential values (Fig. 9D, left and center panels) and the mean increase of the first PSP during up states (n?
Positive_regulation (increase) of PSP in PSP
20) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0.31 Pain Relevance 0.09

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