INT295676

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 6.05
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL8) extracellular space (CCL8) extracellular region (CCL8)
cell-cell signaling (CCL8)
Anatomy Link Frequency
macrophage 2
monocyte 1
eosinophil 1
CCL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 154 100.00 Very High Very High Very High
Inflammation 130 100.00 Very High Very High Very High
chemokine 52 100.00 Very High Very High Very High
fibrosis 6 100.00 Very High Very High Very High
Inflammatory response 8 40.64 Quite Low
metalloproteinase 204 5.00 Very Low Very Low Very Low
COX-2 inhibitor 46 5.00 Very Low Very Low Very Low
aspirin 10 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
cocaine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 142 100.00 Very High Very High Very High
Malignant Neoplastic Disease 8 100.00 Very High Very High Very High
Fibrosis 2 100.00 Very High Very High Very High
Infection 208 99.74 Very High Very High Very High
Herpes Simplex Virus 476 99.54 Very High Very High Very High
Rhinitis 124 93.84 High High
Polyps 26 93.08 High High
Eczema 62 90.48 High High
Asthma 34 75.64 Quite High
Chronic Sinusitis 28 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These included increased transcription of chemokines localized to chromosome 17q11.2 (CCL13, CCL2, CCL8, and CCL11) that favor eosinophil and monocyte chemotaxis and chemokines (CCL18, CCL22, and CXCL13) that alternatively-activated monocyte-derived cells have been shown to produce.
Localization (localized) of CCL8 in monocyte associated with chemokine
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2897889 Disease Relevance 1.82 Pain Relevance 0.17
These included increased transcription of chemokines localized to chromosome 17q11.2 (CCL13, CCL2, CCL8, and CCL11) that favor eosinophil and monocyte chemotaxis and chemokines (CCL18, CCL22, and CXCL13) that alternatively-activated monocyte-derived cells have been shown to produce.
Localization (localized) of CCL8 in eosinophil associated with chemokine
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2897889 Disease Relevance 1.82 Pain Relevance 0.17
Compared to uninfected cells, KSHV infection induced the secretion of chemotactic cytokines (chemokines) that mediate leukocyte recruitment to sites of inflammation, fibrosis, and malignancy such as RANTES, macrophage chemoattractant protein-2 (MCP-2), MCP-3, thymus and activation-regulated chemokine (TARC), macrophage inflammatory protein (MIP-1?)
Localization (secretion) of macrophage chemoattractant protein-2 in macrophage associated with fibrosis, chemokine, malignant neoplastic disease, inflammation, herpes simplex virus, infection and cytokine
3) Confidence 0.08 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.21 Pain Relevance 0.88
Compared to uninfected cells, KSHV infection induced the secretion of chemotactic cytokines (chemokines) that mediate leukocyte recruitment to sites of inflammation, fibrosis, and malignancy such as RANTES, macrophage chemoattractant protein-2 (MCP-2), MCP-3, thymus and activation-regulated chemokine (TARC), macrophage inflammatory protein (MIP-1?)
Localization (secretion) of MCP-2 in macrophage associated with fibrosis, chemokine, malignant neoplastic disease, inflammation, herpes simplex virus, infection and cytokine
4) Confidence 0.08 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.21 Pain Relevance 0.88

General Comments

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