INT295679

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.70
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 204 100.00 Very High Very High Very High
cytokine 152 100.00 Very High Very High Very High
Inflammation 80 97.40 Very High Very High Very High
COX-2 inhibitor 46 31.68 Quite Low
chemokine 40 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 88 97.40 Very High Very High Very High
Herpes Simplex Virus 476 90.84 High High
Infection 208 87.92 High High
Sarcoma 158 87.00 High High
Adhesions 84 80.88 Quite High
Wound Healing 2 57.52 Quite High
Metastasis 6 56.92 Quite High
Cancer 40 55.96 Quite High
Vascular Neoplasms 2 55.76 Quite High
Apoptosis 16 42.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This data also supported the cytokine antibody array data (Table S4), where pretreatment of cells by NS-398 up-regulated the release of TIMP-2 by 2.1 fold at 24 h PI.


Regulation (regulated) of Localization (release) of TIMP associated with cytokine
1) Confidence 0.17 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.84 Pain Relevance 0.57
Infected HMVEC-d and TIVE-LTC cells secreted a variety of ICs, GFs, angiogenic factors and matrix metalloproteinases (MMPs), which were significantly abrogated by COX-2 inhibition either by chemical inhibitors or by siRNA.
Regulation (abrogated) of Localization (variety) of metalloproteinases associated with metalloproteinase and cytokine
2) Confidence 0.15 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2820536 Disease Relevance 1.86 Pain Relevance 0.37

General Comments

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