INT29568

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Context Info
Confidence 0.50
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.83
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bpifa2) extracellular region (Bpifa2) biological_process (Bpifa2)
Anatomy Link Frequency
PSP 8
Bpifa2 (Mus musculus)
Pain Link Frequency Relevance Heat
shoulder pain 7 100.00 Very High Very High Very High
cINOD 1 99.78 Very High Very High Very High
Analgesic 3 97.84 Very High Very High Very High
diclofenac 8 97.26 Very High Very High Very High
Pain 1 93.20 High High
Action potential 2 92.20 High High
Inflammation 19 91.28 High High
corticosteroid 1 87.68 High High
tetrodotoxin 13 87.28 High High
Osteoarthritis 3 84.36 Quite High
Disease Link Frequency Relevance Heat
Shoulder Pain 7 100.00 Very High Very High Very High
Corneal Neovascularization 39 99.84 Very High Very High Very High
INFLAMMATION 21 99.66 Very High Very High Very High
Pain 1 93.20 High High
Bursitis 2 85.36 High High
Osteoarthritis 3 84.36 Quite High
Ganglion Cysts 63 78.08 Quite High
Cancer 3 66.48 Quite High
Corneal Disease 3 38.16 Quite Low
Burns 10 27.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A reduced level of PSP activity occurred in 7% (4/58) of cells exhibiting excitatory PSPs and in 10% (6/58) of cells with inhibitory connections.
Negative_regulation (reduced) of PSP in PSP
1) Confidence 0.50 Published 1988 Journal Brain Res. Section Abstract Doc Link 2837312 Disease Relevance 0 Pain Relevance 0.21
Oral nonsteroidal anti-inflammatory drugs are often prescribed for patients with PSP, but their use may be complicated by gastrointestinal side effects and a potential for increased risk for serious cardiovascular events.
Negative_regulation (prescribed) of PSP in PSP associated with inflammation, cinod and shoulder pain
2) Confidence 0.36 Published 2005 Journal Am J. Orthop. Section Abstract Doc Link 16450691 Disease Relevance 1.07 Pain Relevance 0.94
In this assay, we found PSP treatment could dramatically decrease the amount of phosphorylated AKT and ERK1/2 in HUVECs, implying that the potential molecular mechanism of PSP inhibition of CNV may be partly attributed to its inhibition effect on the activation of AKT and ERK1/2 phosphorylation.
Negative_regulation (inhibition) of PSP in PSP associated with corneal neovascularization
3) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2751803 Disease Relevance 0.68 Pain Relevance 0.17
In contrast to the PSP acetone revealed as inhibitor in the BFR.
Negative_regulation (inhibitor) of PSP in PSP
4) Confidence 0.08 Published 2003 Journal Sci. Total Environ. Section Abstract Doc Link 12798104 Disease Relevance 0 Pain Relevance 0.19
Clofibric acid and diclofenac were not eliminated and reached a level of approximately 95% of their initial concentration, whereas the concentration of ibuprofen was decreased to approximately 40% in the PSP and to approximately 35% in the oxic BFR.
Negative_regulation (decreased) of PSP in PSP associated with diclofenac
5) Confidence 0.07 Published 2003 Journal Sci. Total Environ. Section Abstract Doc Link 12798104 Disease Relevance 0 Pain Relevance 0.25
Further, because the soma is hyperpolarized 5–10 mV below spike threshold, any dendritic PSP that propagates toward the soma also tends to be attenuated and hyperpolarized, reducing the probability that it will reach spike threshold after back- propagating distally.


Negative_regulation (attenuated) of PSP in PSP
6) Confidence 0.06 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2924322 Disease Relevance 0.08 Pain Relevance 0
The on-path inhibition also attenuated the dendritic PSP produced by excitatory input (Figure 6b,c gray traces).
Negative_regulation (attenuated) of PSP in PSP
7) Confidence 0.06 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2924322 Disease Relevance 0 Pain Relevance 0
We hypothesized that this directional difference was due to local inhibition that suppressed dendritic spike initiation in the null direction without reducing somatic PSP amplitude.


Negative_regulation (reducing) of PSP in PSP
8) Confidence 0.06 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2924322 Disease Relevance 0 Pain Relevance 0

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