INT295694

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.28
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (DNAI1) cilium (DNAI1) cytoplasm (DNAI1)
Anatomy Link Frequency
d cells 1
DNAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 180 100.00 Very High Very High Very High
Inflammation 110 99.68 Very High Very High Very High
metalloproteinase 204 98.52 Very High Very High Very High
agonist 7 77.84 Quite High
Inflammatory response 5 76.40 Quite High
adenocard 1 41.20 Quite Low
chemokine 46 35.52 Quite Low
COX-2 inhibitor 46 25.00 Low Low
fibrosis 2 21.36 Low Low
psoriasis 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 118 99.68 Very High Very High Very High
Infection 224 98.88 Very High Very High Very High
Herpes Simplex Virus 477 98.68 Very High Very High Very High
Sarcoma 159 87.44 High High
Disease Progression 5 86.16 High High
Cancer 48 83.80 Quite High
Skin Cancer 29 80.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 130 79.04 Quite High
Apoptosis 20 74.12 Quite High
Adhesions 85 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infected HMVEC-d and TIVE-LTC cells secreted a variety of ICs, GFs, angiogenic factors and matrix metalloproteinases (MMPs), which were significantly abrogated by COX-2 inhibition either by chemical inhibitors or by siRNA.
Localization (secreted) of ICs associated with metalloproteinase and cytokine
1) Confidence 0.15 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2820536 Disease Relevance 1.72 Pain Relevance 0.37
Compared to uninfected HMVEC-d cells, KSHV infection triggered an appreciable (1.5-2) fold induction in the secretion of pro-ICs, such as growth regulated oncogene (GRO), GRO?
Localization (secretion) of ICs in d cells associated with herpes simplex virus, infection and cytokine
2) Confidence 0.11 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.77 Pain Relevance 0.42
The definition of a positive ICS response for all peptide pools (CD4 and CD8) was 0.045%, except CD8 EnvC (0.07%) and CD8 GagB (0.058%).


Localization (response) of ICS
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943475 Disease Relevance 0.18 Pain Relevance 0.05
After extensive studies, the potential of ICs to stimulate secretion of pro-inflammatory cytokines was finally discovered [167, 168].
Localization (secretion) of ICs associated with inflammation and cytokine
4) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.61 Pain Relevance 0.25

General Comments

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