INT295722

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.14
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2, RAC1) cytosol (RAC1) cell motility (RAC1)
cell adhesion (RAC1) enzyme binding (RAC1) GTPase activity (RAC1)
Anatomy Link Frequency
endothelial cells 2
PTGER2 (Homo sapiens)
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 204 91.72 High High
cytokine 152 89.28 High High
Inflammation 80 86.12 High High
COX-2 inhibitor 46 58.32 Quite High
chemokine 40 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 476 100.00 Very High Very High Very High
Infection 208 100.00 Very High Very High Very High
Adhesions 84 100.00 Very High Very High Very High
INFLAMMATION 88 86.12 High High
Sarcoma 158 83.92 Quite High
Apoptosis 16 68.64 Quite High
Vascular Neoplasms 2 44.48 Quite Low
Disease 10 32.80 Quite Low
Cancer 40 25.00 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE2, secreted early during KSHV infection, profoundly increased the adhesion of uninfected endothelial cells to fibronectin by activating the small G protein Rac1.
PGE2 Positive_regulation (activating) of Rac1 in endothelial cells associated with herpes simplex virus, adhesions and infection
1) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2820536 Disease Relevance 1.92 Pain Relevance 0.32
Induction of Rac1-GTPase was 4.8- fold when compared to Rac1-GTPase activity in the presence of uninfected cell culture supernatant suggesting that PGE2 is enough to induce Rac1-GTPase in the adhering endothelial cells.
PGE2 Positive_regulation (induce) of Rac1 in endothelial cells
2) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.22 Pain Relevance 0

General Comments

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