INT29577

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Context Info
Confidence 0.37
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.41
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1) aging (Cyp27b1)
cytoplasm (Cyp27b1)
Cyp27b1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 99.32 Very High Very High Very High
imagery 3 96.00 Very High Very High Very High
Paracetamol 13 94.76 High High
Pain 1 82.24 Quite High
Inflammation 12 79.28 Quite High
Snapping jaw 3 72.20 Quite High
fibrosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 11 97.68 Very High Very High Very High
Asthma 8 90.80 High High
Hypophosphatemia 3 90.52 High High
Pain 1 82.24 Quite High
Recurrence 1 80.08 Quite High
Hemangiopericytoma 2 75.16 Quite High
INFLAMMATION 12 75.00 Quite High
Rickets 4 75.00 Quite High
Temporomandibular Joint Syndrome 3 72.20 Quite High
Hepatotoxicity 2 60.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The movement recordings also showed that the PDDR could be eliminated by submaximal opening and closing movements.
Negative_regulation (eliminated) of PDDR
1) Confidence 0.37 Published 2005 Journal J Orofac Pain Section Abstract Doc Link 16279486 Disease Relevance 0.28 Pain Relevance 0.31
When extracts of the original tumor were added to primary cultures of renal tubular cells, renal cAMP levels did not change, but 25-hydroxyvitamin D-1 alpha-hydroxylase activity was significantly inhibited.
Negative_regulation (inhibited) of alpha-hydroxylase associated with cancer
2) Confidence 0.30 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2837500 Disease Relevance 1.59 Pain Relevance 0.08
Furafylline, a CYP1A inhibitor, and indomethacin, a PGHS inhibitor, exhibited a significant inhibitory effect on TNFalpha and IL-1beta production induced by the APAP and LPS combination.
Negative_regulation (inhibitor) of CYP1A associated with paracetamol
3) Confidence 0.02 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.25 Pain Relevance 1.31
An alternative explanation might be differential compensation in a background of C1P reduction (due to absence of CERK) in the two models.
Negative_regulation (reduction) of C1P
4) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.17 Pain Relevance 0.12
Consistent with these observations, the levels of CYP1A, CYP2A, and CYP3A enzymes were also suppressed, as determined by immunoblotting with antibodies against rat P450 enzymes.
Negative_regulation (suppressed) of CYP1A
5) Confidence 0.01 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7676446 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

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