INT29579

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Context Info
Confidence 0.65
First Reported 1988
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.69
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cilium (BBS9) microtubule organizing center (BBS9) cytoplasm (BBS9)
nucleolus (BBS9) nucleus (BBS9) cytoskeleton (BBS9)
Anatomy Link Frequency
C16 3
renal tubules 1
BBS9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 9 100.00 Very High Very High Very High
Pain 13 76.24 Quite High
Enkephalin 2 61.68 Quite High
Neuropathic pain 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 18 99.36 Very High Very High Very High
Diabetes Mellitus 108 95.68 Very High Very High Very High
Cancer 10 89.36 High High
Hypophosphatemia 3 84.52 Quite High
Pain 13 76.24 Quite High
Rickets 4 75.00 Quite High
Hemangiopericytoma 2 75.00 Quite High
Obesity 6 61.60 Quite High
Syndrome 2 53.08 Quite High
Nicotine Addiction 3 48.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate tumoral production of some humoral factor(s) inhibiting 25-hydroxyvitamin D-1 alpha-hydroxylase activity and phosphorus reabsorption unrelated to adenylate cyclase-cAMP production in proximal renal tubules.
Gene_expression (production) of D-1 in renal tubules
1) Confidence 0.65 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2837500 Disease Relevance 1.30 Pain Relevance 0.08
PC2 cleaved proDyn to produce dynorphin (Dyn) A 1-17, Dyn B 1-13, and alpha-neo-endorphin, without a previous requirement for PC1/PC3.
Neg (without) Gene_expression (produce) of B 1 associated with dynorphin
2) Confidence 0.65 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9422738 Disease Relevance 0 Pain Relevance 0.43
This indicates that DSB generation is metabolically independent from C16 and C18-sphingoid base formation.
Gene_expression (formation) of C18 in C16
3) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.24 Pain Relevance 0
The C16-and the C18-sphingolipids were found in the LDL and HDL but not in the VLDL fraction.
Neg (not) Gene_expression (found) of C18 in C16 associated with disorder of lipid metabolism
4) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.62 Pain Relevance 0
It was recently shown that increasing L-alanine levels stimulate DSB formation, whereas the presence of L-serine suppresses DSB formation and increases the generation of C16 and C18 sphingoid bases [12].
Gene_expression (generation) of C18 in C16
5) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.53 Pain Relevance 0

General Comments

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