INT2958

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Context Info
Confidence 0.71
First Reported 1979
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 2.57
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
ganglia 2
plasma 1
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 10 100.00 Very High Very High Very High
fortral 1 99.62 Very High Very High Very High
cva 5 98.52 Very High Very High Very High
withdrawal 5 98.08 Very High Very High Very High
Neuropeptide 11 95.00 High High
Enkephalin 8 94.28 High High
Clonidine 6 91.52 High High
medulla 10 89.20 High High
Catecholamine 5 75.00 Quite High
noradrenaline 1 64.32 Quite High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 5 99.04 Very High Very High Very High
Stress 24 98.62 Very High Very High Very High
Hypoxia 1 98.54 Very High Very High Very High
Hypotension 1 93.60 High High
Heart Rate Under Development 1 92.84 High High
Pressure And Volume Under Development 1 79.44 Quite High
Hypertension 1 76.28 Quite High
Intracranial Vasospasm 2 69.16 Quite High
Muscular Spasm 4 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged cortisol administration failed to alter the mRNA levels of TH, DBH, and NPY in control animals but attenuated the response to stress.
Transcription (levels) of DBH associated with stress
1) Confidence 0.71 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.58 Pain Relevance 0.30
The dopamine-beta-hydroxylase activity of the A2/C2 region was also diminished during withdrawal.
Transcription (activity) of dopamine-beta-hydroxylase associated with dopamine and withdrawal
2) Confidence 0.67 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2869960 Disease Relevance 0.34 Pain Relevance 0.91
[Changes in plasma dopamine-beta-hydroxylase activity in patients with acute subarachnoid hemorrhage (author's transl)].
Transcription (activity) of dopamine-beta-hydroxylase in plasma associated with fortral, dopamine, cv general 4 under development and cva
3) Confidence 0.60 Published 1979 Journal No To Shinkei Section Title Doc Link 574016 Disease Relevance 0.60 Pain Relevance 0.42
Here we examined the effect of immobilization stress and treatment with ACTH and glucocorticoids on messenger RNA (mRNA) levels for tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), preproneuropeptide Y (pre-NPY), and proenkephalin in rat superior cervical ganglia (SCG) and in stellate ganglia.
Transcription (levels) of DBH in ganglia associated with stress and dopamine
4) Confidence 0.53 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.47 Pain Relevance 0.29
Here we examined the effect of immobilization stress and treatment with ACTH and glucocorticoids on messenger RNA (mRNA) levels for tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), preproneuropeptide Y (pre-NPY), and proenkephalin in rat superior cervical ganglia (SCG) and in stellate ganglia.
Transcription (levels) of dopamine beta-hydroxylase in ganglia associated with stress and dopamine
5) Confidence 0.53 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.47 Pain Relevance 0.29
We report here that maternal hypoxia (11-13% O2) leads to 2-3-fold increases (p < 0.01) in fetal adrenal TH, DBH, and NPY mRNA levels on the day before birth.
Transcription (levels) of DBH associated with hypoxia
6) Confidence 0.44 Published 1995 Journal Pediatr. Res. Section Abstract Doc Link 7651752 Disease Relevance 0.10 Pain Relevance 0.42

General Comments

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