INT29582

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 8.30
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cilium (BBS9) microtubule organizing center (BBS9) cytoplasm (BBS9)
nucleolus (BBS9) nucleus (BBS9) cytoskeleton (BBS9)
Anatomy Link Frequency
C16 1
renal tubules 1
BBS9 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 99.64 Very High Very High Very High
Morphine 4 98.56 Very High Very High Very High
agonist 17 96.56 Very High Very High Very High
Dopamine 6 96.08 Very High Very High Very High
Pain 12 82.40 Quite High
Substantia nigra 1 78.28 Quite High
Enkephalin 1 75.36 Quite High
dopamine receptor 1 75.00 Quite High
fibrosis 11 26.76 Quite Low
Inflammation 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 40 99.80 Very High Very High Very High
Hypophosphatemia 12 99.60 Very High Very High Very High
Catalepsy 2 98.88 Very High Very High Very High
Rickets 16 98.40 Very High Very High Very High
Hemangiopericytoma 8 97.98 Very High Very High Very High
Syndrome 10 96.40 Very High Very High Very High
Diabetes Mellitus 89 94.52 High High
Obesity 15 84.80 Quite High
Pain 12 82.40 Quite High
Starvation 8 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity.
Negative_regulation (inhibit) of D 1 associated with cancer, rickets, hemangiopericytoma and hypophosphatemia
1) Confidence 0.57 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 2837500 Disease Relevance 1.82 Pain Relevance 0.07
The administration of SCH 32615 (3 mg/kg) decreased both D-1 and D-2 antagonist-induced catalepsy.
Negative_regulation (decreased) of D-1 associated with catalepsy and antagonist
2) Confidence 0.57 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7566505 Disease Relevance 0.19 Pain Relevance 0.83
When extracts of the original tumor were added to primary cultures of renal tubular cells, renal cAMP levels did not change, but 25-hydroxyvitamin D-1 alpha-hydroxylase activity was significantly inhibited.
Negative_regulation (inhibited) of D-1 associated with cancer
3) Confidence 0.42 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2837500 Disease Relevance 1.59 Pain Relevance 0.08
These data indicate tumoral production of some humoral factor(s) inhibiting 25-hydroxyvitamin D-1 alpha-hydroxylase activity and phosphorus reabsorption unrelated to adenylate cyclase-cAMP production in proximal renal tubules.
Negative_regulation (inhibiting) of D-1 in renal tubules
4) Confidence 0.41 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2837500 Disease Relevance 1.36 Pain Relevance 0.08
Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity.
Negative_regulation (inhibit) of D 1 associated with cancer, rickets, hemangiopericytoma and hypophosphatemia
5) Confidence 0.41 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 2837500 Disease Relevance 1.82 Pain Relevance 0.07
Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning.
Negative_regulation (Blockade) of D-1 associated with morphine
6) Confidence 0.41 Published 1987 Journal Eur. J. Pharmacol. Section Title Doc Link 3556198 Disease Relevance 0 Pain Relevance 0.36
Members of the CYP4B subfamily metabolize SCFAs (C7–C9), while members of the CYP4A subfamily metabolize MCFAs (C10–C16), and members of the CYP4F subfamily metabolize LCFA and VLCFA (C18–C26) fatty acids.
Negative_regulation (metabolize) of C18 in C16
7) Confidence 0.41 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.47 Pain Relevance 0
However, lower levels of serine should then also be associated with lower C18 and C18 sphingoid base levels.
Negative_regulation (lower) of C18
8) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.52 Pain Relevance 0
However, lower levels of serine should then also be associated with lower C18 and C18 sphingoid base levels.
Negative_regulation (lower) of C18
9) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.52 Pain Relevance 0

General Comments

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