INT295820

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Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.35
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Srsf1) mRNA processing (Srsf1) RNA binding (Srsf1)
nucleus (Srsf1) cytoplasm (Srsf1)
Anatomy Link Frequency
proximal 1
epithelial cells 1
nucleus 1
Srsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 7 76.16 Quite High
agonist 7 67.36 Quite High
anesthesia 7 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 7 95.92 Very High Very High Very High
Leukemia 7 92.04 High High
Apoptosis 7 78.40 Quite High
Cancer 49 73.60 Quite High
Retinal Neovascularization 21 46.88 Quite Low
Lung Cancer 7 42.52 Quite Low
Targeted Disruption 7 41.16 Quite Low
Hypoxia 14 40.36 Quite Low
Sarcoma 7 39.44 Quite Low
Skin Cancer 14 31.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These two kinases are able to phosphorylate the splicing factor, ASF/SF2 and all these components are involved in the choice of the PSS in VEGF.
Phosphorylation (phosphorylate) of ASF/SF2
1) Confidence 0.71 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.48 Pain Relevance 0
Moreover, SRPK1 and SRPK2 are known to phosphorylate the ASF/SF2 splicing factor with high specificity (21, 31, 53).
Phosphorylation (phosphorylate) of ASF/SF2
2) Confidence 0.71 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.42 Pain Relevance 0
SRPK1 has been shown to phosphorylate ASF/SF2, which we have previously shown to favor proximal splice site selection.
Phosphorylation (phosphorylate) of ASF/SF2 in proximal
3) Confidence 0.71 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
It thus appears likely that SRPK1-mediated phosphorylation of ASF/SF2 could support an activation of the PSS and increased production of pro-angiogenic isoforms.
Phosphorylation (phosphorylation) of ASF/SF2
4) Confidence 0.71 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.13 Pain Relevance 0
These results indicate that an overactivity of SRPK1 can cause phosphorylation of ASF/SF2.
Phosphorylation (phosphorylation) of ASF/SF2
5) Confidence 0.71 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.33 Pain Relevance 0
SRPK1 has been shown specifically to phosphorylate 12 serines of the RS domain in ASF/SF2 (31), and SRPK2 has been involved in the localization of ASF/SF2 within the nucleus.
Phosphorylation (phosphorylate) of ASF/SF2 in nucleus
6) Confidence 0.71 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.03
To determine the mechanism by which the pro-angiogenic splice site choice is mediated, we investigated the effect of inhibition of ASF/SF2 phosphorylation by SR protein kinases (SRPK1/2) on splice site choice in epithelial cells and in in vivo angiogenesis models.
Phosphorylation (phosphorylation) of ASF/SF2 in epithelial cells
7) Confidence 0.55 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.04

General Comments

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