INT295824

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.39
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Srpk1) chromosome segregation (Srpk1) mRNA processing (Srpk1)
nucleus (Srpk1) kinase activity (Srpk1) cytoplasm (Srpk1)
Anatomy Link Frequency
proximal 2
epithelial cells 2
Srpk1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 99.92 Very High Very High Very High
anesthesia 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 4 81.52 Quite High
Leukemia 4 77.64 Quite High
Apoptosis 4 64.00 Quite High
Cancer 28 59.20 Quite High
Lung Cancer 4 28.12 Quite Low
Targeted Disruption 4 26.76 Quite Low
Sarcoma 4 25.04 Quite Low
Hypoxia 8 21.52 Low Low
Retinal Neovascularization 12 19.92 Low Low
Skin Cancer 8 16.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that the IGF-1-mediated increase in VEGF isoforms using the proximal splice site is inhibited by blocking PKC and SRPK1/2, and that this can be overcome by the use of a PKC inhibitor or mimicked by a PKC agonist or overexpression of SRPK1.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SRPK1 in proximal associated with agonist
1) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.05
Fig. 3D shows that overexpression of SRPK1, but not SRPK2, resulted in reduced distal splice site selection and hence reduced overall VEGF levels.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SRPK1
2) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
To confirm the involvement of SRPK1 or SRPK2 in the terminal splice site choice, epithelial cells were transfected with expression vectors to overexpress SRPK1 and SRPK2.
Positive_regulation (overexpress) of Gene_expression (overexpress) of SRPK1 in epithelial cells
3) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
These results indicate that an overactivity of SRPK1 can cause phosphorylation of ASF/SF2.
Positive_regulation (overactivity) of Gene_expression (overactivity) of SRPK1
4) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.39 Pain Relevance 0

General Comments

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