INT295828

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Srpk2) mRNA processing (Srpk2) nucleolus (Srpk2)
nucleus (Srpk2) kinase activity (Srpk2) cytoplasm (Srpk2)
Anatomy Link Frequency
epithelial cells 2
Srpk2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 6 99.60 Very High Very High Very High
Leukemia 6 99.56 Very High Very High Very High
Apoptosis 6 88.44 High High
Cancer 42 83.64 Quite High
Lung Cancer 6 52.56 Quite High
Targeted Disruption 6 51.20 Quite High
Sarcoma 6 49.48 Quite Low
Skin Cancer 12 41.32 Quite Low
Breast Cancer 6 39.36 Quite Low
Colon Cancer 12 38.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SRPK2 and acinus were also overexpressed in human acute myelogenous leukemia patients and correlate with elevated cyclin A1 expression levels (52).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of SRPK2 associated with acute myeloid leukemia
1) Confidence 0.32 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.57 Pain Relevance 0
Interestingly, SRPK2 overexpression did not affect VEGF165b production, although it did reduce total VEGF expression.


Positive_regulation (overexpression) of Gene_expression (overexpression) of SRPK2
2) Confidence 0.32 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Moreover, overexpression of acinus or SRPK2 increased leukemia cell proliferation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SRPK2 associated with leukemia
3) Confidence 0.28 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.68 Pain Relevance 0
Fig. 3D shows that overexpression of SRPK1, but not SRPK2, resulted in reduced distal splice site selection and hence reduced overall VEGF levels.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SRPK2
4) Confidence 0.23 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
To confirm the involvement of SRPK1 or SRPK2 in the terminal splice site choice, epithelial cells were transfected with expression vectors to overexpress SRPK1 and SRPK2.
Positive_regulation (overexpress) of Gene_expression (overexpress) of SRPK2 in epithelial cells
5) Confidence 0.23 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Moreover, overexpression of acinus or SRPK2 increased leukemia cell proliferation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SRPK2 associated with leukemia
6) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.68 Pain Relevance 0

General Comments

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