INT29583

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Context Info
Confidence 0.45
First Reported 1983
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 30
Total Number 32
Disease Relevance 21.47
Pain Relevance 7.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Agtr2) transcription factor binding (Agtr2) signal transducer activity (Agtr2)
Anatomy Link Frequency
liver 3
neuronal 2
blood 2
smooth muscle 1
kidney 1
Agtr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 77 100.00 Very High Very High Very High
Glutamate receptor 8 100.00 Very High Very High Very High
Clonidine 6 100.00 Very High Very High Very High
Potency 4 100.00 Very High Very High Very High
antagonist 50 99.96 Very High Very High Very High
opioid receptor 9 99.80 Very High Very High Very High
depression 1 99.60 Very High Very High Very High
tricyclic antidepressant 4 98.78 Very High Very High Very High
Desipramine 5 98.20 Very High Very High Very High
Angina 9 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 1 99.60 Very High Very High Very High
Cancer 660 99.52 Very High Very High Very High
Pituitary Cancer 44 99.48 Very High Very High Very High
Increased Venous Pressure Under Development 39 99.44 Very High Very High Very High
Apoptosis 231 99.34 Very High Very High Very High
Colon Cancer 385 99.32 Very High Very High Very High
Metastasis 143 99.26 Very High Very High Very High
Hypoxia 40 99.12 Very High Very High Very High
Hypertrophy 5 98.64 Very High Very High Very High
Diabetes Mellitus 66 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats.
Positive_regulation (upregulated) of angiotensin II type-2 associated with diuresis, natriuresis and obesity
1) Confidence 0.45 Published 2005 Journal Hypertension Section Title Doc Link 15596573 Disease Relevance 0.98 Pain Relevance 0.19
The results suggest that activation of AT2 receptors increases jejunal luminal NO output.
Positive_regulation (activation) of AT2
2) Confidence 0.34 Published 2003 Journal BMC Pharmacol Section Abstract Doc Link PMC153509 Disease Relevance 0 Pain Relevance 0.15
AT2-receptor mediated NO dependent functional alterations have been reported also in the gastrointestinal tract [6] but direct measurements of NO synthesis in response to AT2-receptor activation in the intestine have not until now been reported.
Positive_regulation (activation) of AT2 in intestine
3) Confidence 0.34 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0.21 Pain Relevance 0.16
The results suggest that activation of AT2 receptors increases jejunal luminal NO output.
Positive_regulation (activation) of AT2
4) Confidence 0.34 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0.14 Pain Relevance 0.21
A syngenic orthotopic model of CRC liver metastases was used to assess the potential of AT2R activation (via CGP42112A) to inhibit tumour growth.
Positive_regulation (activation) of AT2R in liver associated with cancer, colon cancer and metastasis
5) Confidence 0.27 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.13 Pain Relevance 0
Activation of the AT2R (either by endogenous ligand or CGP42112A) has been shown to increase eNOS levels in the developing pig [32] and nNOS in the rat kidney[33].
Positive_regulation (Activation) of AT2R in kidney
6) Confidence 0.27 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.76 Pain Relevance 0.05
A2R binding sites were also increased 21% in exposed neurons measured by radioligand [(3)H]rauwolscine binding assay.
Positive_regulation (increased) of A2R in neurons
7) Confidence 0.26 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842765 Disease Relevance 0.68 Pain Relevance 0.67
In response to the alpha-2 adrenoceptor (A2R) agonist clonidine, both the hyperpolarizing potency and efficacy were increased indicated by a decreased EC(50) (control: 30.9 nM and exposed: 19.7 nM) and a 50.5% increase in maximum hyperpolarized potential, respectively.
Positive_regulation (increased) of A2R associated with agonist, potency and clonidine
8) Confidence 0.26 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842765 Disease Relevance 0.72 Pain Relevance 0.65
The results suggested that up-regulation of A2R and altered non-NMDA glutamate receptor function induced by chronic hypobaric hypoxia may underlie, in part, the decreased LC neuronal excitability and acute hypoxia tolerance.
Positive_regulation (induced) of A2R in neuronal associated with neuronal excitability, hypoxia, locus ceruleus, glutamate receptor and tolerance
9) Confidence 0.26 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842765 Disease Relevance 0.54 Pain Relevance 0.71
The results suggested that up-regulation of A2R and altered non-NMDA glutamate receptor function induced by chronic hypobaric hypoxia may underlie, in part, the decreased LC neuronal excitability and acute hypoxia tolerance.
Positive_regulation (up-regulation) of A2R in neuronal associated with neuronal excitability, hypoxia, locus ceruleus, glutamate receptor and tolerance
10) Confidence 0.26 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842765 Disease Relevance 0.53 Pain Relevance 0.74
In contrast to these inhibitory presynaptic mechanisms, facilitation of norepinephrine release appears to occur by way of neuronal angiotensin II receptor activation and perhaps through stimulation of sympathetic nerve membrane beta 2-receptors.
Positive_regulation (activation) of angiotensin II receptor in sympathetic
11) Confidence 0.20 Published 1988 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 2837502 Disease Relevance 0.39 Pain Relevance 0.34
PLA2, a key signalling molecule induced by AT2R activation [18,19], showed a similar result with increased staining corresponding to increasing concentrations of CGP42112A treatment (Figure 3B).
Positive_regulation (activation) of AT2R
12) Confidence 0.19 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.86 Pain Relevance 0
These results suggest that AT2R activation might provide a novel target to inhibit tumour growth.
Positive_regulation (activation) of AT2R associated with cancer
13) Confidence 0.18 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2902462 Disease Relevance 1.01 Pain Relevance 0.03
Despite the pro-angiogenic effects of CGP42112A, and perhaps as a consequence of its apoptotic and anti-proliferative effects, AT2R activation resulted in a significant reduction in the liver to body weight ratio, indicating a reduced tumour burden in the liver.
Positive_regulation (activation) of AT2R in liver associated with body weight, cancer and apoptosis
14) Confidence 0.18 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.71 Pain Relevance 0
Alternatively, if AT2R activation does indeed increase angiogenesis this effect could be counteracted by a combination with anti-angiogenic therapies.


Positive_regulation (activation) of AT2R
15) Confidence 0.18 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.96 Pain Relevance 0
This study examined the effect of AT2R activation with the agonist CGP42112A in a mouse model of CRC liver metastases.


Spec (examined) Positive_regulation (activation) of AT2R in liver associated with colon cancer, agonist and metastasis
16) Confidence 0.18 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2902462 Disease Relevance 1.19 Pain Relevance 0.05
While, this increase failed to reach significance, evidence for a pro-angiogenic role of AT2R activation is indicated by the increase in VEGF secreted by MoCR cells both in vivo (Figure 6B) and in vitro (Figure 6C).
Positive_regulation (activation) of AT2R associated with colon cancer
17) Confidence 0.18 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.64 Pain Relevance 0
AT2R activation has, however, also been shown to inhibit VEGF signalling [9] and angiogenesis [10], suggesting it can mediate both pro- and anti-angiogenic actions.
Positive_regulation (activation) of AT2R
18) Confidence 0.18 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.21 Pain Relevance 0.10
A few studies have investigated the effect of targeting the MasR, via infusion of its ligand ANG-(1-7)[24-26], but no studies have examined the potential of AT2R activation in an anti-cancer setting.
Spec (examined) Positive_regulation (activation) of AT2R associated with cancer
19) Confidence 0.18 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.05 Pain Relevance 0.04
rtPCR AT1 and AT2 receptors
Positive_regulation (rtPCR) of AT2
20) Confidence 0.16 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0 Pain Relevance 0

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