INT295834

Context Info Confidence 0.41 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

cell differentiation (Srpk1) chromosome segregation (Srpk1) mRNA processing (Srpk1) nucleus (Srpk1) kinase activity (Srpk1) cytoplasm (Srpk1)

Anatomy Link Frequency proximal 1 Srpk1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 2 34.00 anesthesia 2 5.00 Kinase C 2 5.00 isoflurane 2 5.00 imagery 2 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Repression 2 17.52 Cancer 14 5.00 Ocular Toxicity (including Many Sub-types) 10 5.00 Diabetic Retinopathy 10 5.00 Retinal Neovascularization 6 5.00 Hypoxia 4 5.00 Skin Cancer 4 5.00 Glaucoma 4 5.00 Pathologic Neovascularization 4 5.00 Colon Cancer 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the finding that ASF/SF2, a known splicing factor, requires the presence of a specific short sequence in the polypyrimidine tract upstream of the proximal splice site and that ASF/SF2 is induced to nuclear localization by SRPK1 activation and IGF-1 activation strongly suggest that this is a splicing mechanism rather than a degradation mechanism.

Positive_regulation (activation) of SRPK1 in proximal

1) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0

This localization was inhibited by SRPIN340 (Fig. 4, B versus D), indicating that IGF1-mediated activation of SRPK1/2 was responsible for the nuclear localization of ASF/SF2.

Positive_regulation (activation) of SRPK1

2) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0

General Comments

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