INT295836

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Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 0.16
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Srsf1) mRNA processing (Srsf1) RNA binding (Srsf1)
nucleus (Srsf1) cytoplasm (Srsf1)
Anatomy Link Frequency
nucleus 4
podocytes 1
Srsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 11 97.12 Very High Very High Very High
agonist 11 72.56 Quite High
anesthesia 11 5.00 Very Low Very Low Very Low
isoflurane 11 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
alcohol 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinal Neovascularization 33 79.60 Quite High
Hypoxia 22 36.60 Quite Low
Cancer 77 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 55 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 55 5.00 Very Low Very Low Very Low
Skin Cancer 22 5.00 Very Low Very Low Very Low
Glaucoma 22 5.00 Very Low Very Low Very Low
Pathologic Neovascularization 22 5.00 Very Low Very Low Very Low
Colon Cancer 22 5.00 Very Low Very Low Very Low
Repression 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore investigated ASF/SF2 localization in these and another cell type, HEK293 cells.
Localization (localization) of ASF/SF2
1) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
This localization was inhibited by SRPIN340 (Fig. 4, B versus D), indicating that IGF1-mediated activation of SRPK1/2 was responsible for the nuclear localization of ASF/SF2.
Localization (localization) of ASF/SF2
2) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
It has previously been demonstrated that ASF/SF2 can be shuttled from the nucleus to the cytoplasm in HeLa cells, but is predominantly nuclear.
Localization (shuttled) of ASF/SF2 in nucleus
3) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
SRPK1 has been shown specifically to phosphorylate 12 serines of the RS domain in ASF/SF2 (31), and SRPK2 has been involved in the localization of ASF/SF2 within the nucleus.
Localization (localization) of ASF/SF2 in nucleus
4) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.04
Untreated cells (Fig. 4A) contained both nuclear and cytoplasmic ASF/SF2, whereas after treatment with IGF-1, ASF/SF2 localized specifically to the nucleus (Fig. 4B).
Localization (localized) of ASF/SF2 in nucleus
5) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
To determine whether IGF-1 altered ASF/SF2 localization, podocytes were treated with 100 nm IGF and stained for ASF/SF2.
Localization (localization) of ASF/SF2 in podocytes
6) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Untreated cells (Fig. 4A) contained both nuclear and cytoplasmic ASF/SF2, whereas after treatment with IGF-1, ASF/SF2 localized specifically to the nucleus (Fig. 4B).
Localization (localized) of ASF/SF2 in nucleus
7) Confidence 0.61 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
This subcellular localization of ASF/SF2 was confirmed by the use of a second ASF/SF2 antibody.
Localization (localization) of ASF/SF2
8) Confidence 0.61 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
This localization was inhibited by SRPIN340 (Fig. 4, B versus D), indicating that IGF1-mediated activation of SRPK1/2 was responsible for the nuclear localization of ASF/SF2.
Localization (localization) of ASF/SF2
9) Confidence 0.61 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
IGF-1 treatment resulted in nuclear localization of ASF/SF2, which was blocked by SPRK1/2 inhibition.
Localization (localization) of ASF/SF2
10) Confidence 0.61 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2820781 Disease Relevance 0.08 Pain Relevance 0.05
IGF-1 treatment resulted in nuclear localization of ASF/SF2, which was blocked by SPRK1/2 inhibition.
Localization (localization) of ASF/SF2
11) Confidence 0.61 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2820781 Disease Relevance 0.08 Pain Relevance 0.05

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